Topo IIIβ-1 (Q84) Peptide 
Datasheet
COA
MSDS
SHIP
Product Name :
Topo IIIβ-1 (Q84) Peptide Applications :
Blocking Background :
DNA topoisomerases are nuclear enzymes that regulate the topological structure of DNA by transiently breaking and rejoining DNA strands. Although DNA topoisomerase I and DNA topoisomerase II relax both positive and negative supercoils, DNA topoisomerase III relaxes only negative supercoils. DNA topoisomerase III α exists as a long and a short isoform, which are produced by alternative splicing. DNA topoisomerase III α, which localizes to the nucleolus, is constitutively expressed and remains at high levels throughout the cell cycle in HL-60 cells. DNA topoisomerase III β exists as three isoforms, namely β1, β2 and β3, also produced by alternative splicing. DNA topoisomerase III β1 is expressed in testes, heart and skeletal muscle, whereas β2 is expressed in thymus, kidney and pancreas. Alternative Name :
TOP3B; TOP3B1; DNA topoisomerase 3-beta-1 Swiss-Prot :
O95985 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide Topo IIIβ-1 (Q84). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS1908 Topo IIIβ-1 (Q84) pAb.
Topo IIIβ-1 (Q84) Peptide Applications :
Blocking Background :
DNA topoisomerases are nuclear enzymes that regulate the topological structure of DNA by transiently breaking and rejoining DNA strands. Although DNA topoisomerase I and DNA topoisomerase II relax both positive and negative supercoils, DNA topoisomerase III relaxes only negative supercoils. DNA topoisomerase III α exists as a long and a short isoform, which are produced by alternative splicing. DNA topoisomerase III α, which localizes to the nucleolus, is constitutively expressed and remains at high levels throughout the cell cycle in HL-60 cells. DNA topoisomerase III β exists as three isoforms, namely β1, β2 and β3, also produced by alternative splicing. DNA topoisomerase III β1 is expressed in testes, heart and skeletal muscle, whereas β2 is expressed in thymus, kidney and pancreas. Alternative Name :
TOP3B; TOP3B1; DNA topoisomerase 3-beta-1 Swiss-Prot :
O95985 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide Topo IIIβ-1 (Q84). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS1908 Topo IIIβ-1 (Q84) pAb.
Blocking peptide available as BS1908PP