PTTG1/2/3 (L149) Peptide 
Datasheet
COA
MSDS
SHIP
Product Name :
PTTG1/2/3 (L149) Peptide Applications :
Blocking Background :
The product of the oncogene PTTG, pituitary tumor transforming gene, is a human homolog of the anaphase-inhibitor vertebrate protein, securin. PTTG is a 22 kDa protein that contains a basic amino-terminal domain and an acidic carboxy-terminal domain, which acts as a transactivation domain when fused to a heterologous DNA binding domain. Human PTTG is overexpressed in Jurkat and is also detected in human thymus, testis, and placenta. PTTG is mainly expressed in the cytoplasm and is also partially localized to the nucleus. Vertebrate PTTG regulates the separin Esp1, which promotes chromatid separation, to overcome the cohesive forces that hold sister chromatids together. This regulatory function of PTTG suggests that defective regulation of cohesion may contribute to cancer by promoting chromosome instability. Although vertebrate PTTG shares cell-cycle functions with its yeast securin counterparts Pds1p and Cut2, none share sequence homology. Alternative Name :
PTTG1; EAP1; HPTTG; MGC126883; MGC138276; PTTG; SECURIN; TUTR1 Swiss-Prot :
O95997 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide PTTG1/2/3 (L149). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS1909 PTTG1/2/3 (L149) pAb.
PTTG1/2/3 (L149) Peptide Applications :
Blocking Background :
The product of the oncogene PTTG, pituitary tumor transforming gene, is a human homolog of the anaphase-inhibitor vertebrate protein, securin. PTTG is a 22 kDa protein that contains a basic amino-terminal domain and an acidic carboxy-terminal domain, which acts as a transactivation domain when fused to a heterologous DNA binding domain. Human PTTG is overexpressed in Jurkat and is also detected in human thymus, testis, and placenta. PTTG is mainly expressed in the cytoplasm and is also partially localized to the nucleus. Vertebrate PTTG regulates the separin Esp1, which promotes chromatid separation, to overcome the cohesive forces that hold sister chromatids together. This regulatory function of PTTG suggests that defective regulation of cohesion may contribute to cancer by promoting chromosome instability. Although vertebrate PTTG shares cell-cycle functions with its yeast securin counterparts Pds1p and Cut2, none share sequence homology. Alternative Name :
PTTG1; EAP1; HPTTG; MGC126883; MGC138276; PTTG; SECURIN; TUTR1 Swiss-Prot :
O95997 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide PTTG1/2/3 (L149). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS1909 PTTG1/2/3 (L149) pAb.
Blocking peptide available as BS1909PP