HMGB1 (A164) Peptide 
Datasheet
COA
MSDS
SHIP
Product Name :
HMGB1 (A164) Peptide Applications :
Blocking Background :
High mobility group (HMG) proteins 1 and 2 are ubiquitous non-histone components of chromatin. Research suggests that the binding of HMG proteins to DNA induces alterations in the DNA architecture, including DNA bending and unwinding of the helix. HMG proteins synergize with Oct-2, ATF-2, c-Jun and members of the NFκB family to activate transcription. Additional studies indicate that phosphorylation of HMG protein is required to stimulate the transcriptional activity of the protein. Human HMG-1 and HMG-2 each contain two DNA-binding domains, termed HMG boxes. HMG proteins bind singlestranded DNA but induce conformational changes in double-stranded DNA alone. Alternative Name :
High mobility group protein B1; High mobility group protein 1; HMG-1; HMGB1; HMG1 Swiss-Prot :
P09429 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide HMGB1 (A164). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS1918 HMGB1 (A164) pAb.
HMGB1 (A164) Peptide Applications :
Blocking Background :
High mobility group (HMG) proteins 1 and 2 are ubiquitous non-histone components of chromatin. Research suggests that the binding of HMG proteins to DNA induces alterations in the DNA architecture, including DNA bending and unwinding of the helix. HMG proteins synergize with Oct-2, ATF-2, c-Jun and members of the NFκB family to activate transcription. Additional studies indicate that phosphorylation of HMG protein is required to stimulate the transcriptional activity of the protein. Human HMG-1 and HMG-2 each contain two DNA-binding domains, termed HMG boxes. HMG proteins bind singlestranded DNA but induce conformational changes in double-stranded DNA alone. Alternative Name :
High mobility group protein B1; High mobility group protein 1; HMG-1; HMGB1; HMG1 Swiss-Prot :
P09429 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide HMGB1 (A164). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS1918 HMGB1 (A164) pAb.
Blocking peptide available as BS1918PP