CstF-64 (R46) Peptide 
Datasheet
COA
MSDS
SHIP
Product Name :
CstF-64 (R46) Peptide Applications :
Blocking Background :
CstF-64 contains an RNA binding domain and is responsible for the RNA binding activity of CstF. CstF-64 is expressed in all somatic cells and in pre- and postmeiotic, but not meiotic, germ cells. However, a large variant of CstF-64, called t CstF-64, is abundantly expressed in meiotic and postmeiotic cells in the testis and to a lesser extent in the brain, and promotes the germ cell pattern of polyadenylation. The gene encoding CstF-64 (designated CSTF2) maps to the X chromosome, whereas t CstF-64 is encoded by an autosomal gene. The increase in CstF-64 concentration during B cell activation switches IgM heavy chain mRNA expression from membrane-bound to secreted forms, suggesting that CstF-64 plays a key role in regulating IgM heavy chain expression during B cell differentiation. Alternative Name :
Cleavage stimulation factor 64 kDa subunit; CSTF 64 kDa subunit; CF-1 64 kDa subunit; CstF64; CstF 64; CSTF2; Swiss-Prot :
P33240 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide CstF-64 (R46). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS1980 CstF-64 (R46) pAb.
CstF-64 (R46) Peptide Applications :
Blocking Background :
CstF-64 contains an RNA binding domain and is responsible for the RNA binding activity of CstF. CstF-64 is expressed in all somatic cells and in pre- and postmeiotic, but not meiotic, germ cells. However, a large variant of CstF-64, called t CstF-64, is abundantly expressed in meiotic and postmeiotic cells in the testis and to a lesser extent in the brain, and promotes the germ cell pattern of polyadenylation. The gene encoding CstF-64 (designated CSTF2) maps to the X chromosome, whereas t CstF-64 is encoded by an autosomal gene. The increase in CstF-64 concentration during B cell activation switches IgM heavy chain mRNA expression from membrane-bound to secreted forms, suggesting that CstF-64 plays a key role in regulating IgM heavy chain expression during B cell differentiation. Alternative Name :
Cleavage stimulation factor 64 kDa subunit; CSTF 64 kDa subunit; CF-1 64 kDa subunit; CstF64; CstF 64; CSTF2; Swiss-Prot :
P33240 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide CstF-64 (R46). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS1980 CstF-64 (R46) pAb.
Blocking peptide available as BS1980PP