TCF-1 (F26) Peptide 
Datasheet
COA
MSDS
SHIP
Product Name :
TCF-1 (F26) Peptide Applications :
Blocking Background :
T-cell factor-1 (TCF-1) is a DNA-binding transcriptional activator that isessential for lymphoid cell development. The TCF family of transcription factors are activated by the Wnt-1 and Wingless pathways and are characterized by the presence of a conserved protein motif, the high mobility group (HMG) 1 box, which mediates DNA binding. Several alternative splice variants of TCF-1 have been identified, including TCF-1A, which share a conserved amino terminus and differ in the carboxy terminal sequences. The Wnt mediated signaling pathway induces cytosolic β-catenin binding to TCF proteins within the nucleus, leading to the enhanced expression of the Wnt target genes. The β-catenin-TCF complexes are negatively regulated by the adenomatous polyposis coli (APC) tumor suppressor protein, which phosphorylates β-catenin and, in turn, increases the degradation of cytosolic β-catenin and inhibits the transcriptional activity of the TCF proteins. Alternative Name :
Transcription factor 7; TCF-7; T-cell-specific transcription factor 1; T-cell factor 1; TCF-1; TCF7; TCF1 Swiss-Prot :
P36402 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide TCF-1 (F26). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS1987 TCF-1 (F26) pAb.
TCF-1 (F26) Peptide Applications :
Blocking Background :
T-cell factor-1 (TCF-1) is a DNA-binding transcriptional activator that isessential for lymphoid cell development. The TCF family of transcription factors are activated by the Wnt-1 and Wingless pathways and are characterized by the presence of a conserved protein motif, the high mobility group (HMG) 1 box, which mediates DNA binding. Several alternative splice variants of TCF-1 have been identified, including TCF-1A, which share a conserved amino terminus and differ in the carboxy terminal sequences. The Wnt mediated signaling pathway induces cytosolic β-catenin binding to TCF proteins within the nucleus, leading to the enhanced expression of the Wnt target genes. The β-catenin-TCF complexes are negatively regulated by the adenomatous polyposis coli (APC) tumor suppressor protein, which phosphorylates β-catenin and, in turn, increases the degradation of cytosolic β-catenin and inhibits the transcriptional activity of the TCF proteins. Alternative Name :
Transcription factor 7; TCF-7; T-cell-specific transcription factor 1; T-cell factor 1; TCF-1; TCF7; TCF1 Swiss-Prot :
P36402 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide TCF-1 (F26). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS1987 TCF-1 (F26) pAb.
Blocking peptide available as BS1987PP