SMG7 (K548) Peptide 
Datasheet
COA
MSDS
SHIP
Product Name :
SMG7 (K548) Peptide Applications :
Blocking Background :
In humans, NMD depends on RNA-dependent ATPase and 5' to 3' helicase UPF1, plus six other proteins designated SMG1, SMG5, SMG6, SMG7, UPF2 and UPF3. SMG5, SMG7 and UPF1 localize to cytoplasmic foci called P-bodies, while SMG5, SMG6 and SMG7 target UPF1 for dephosphorylation. SMG7 may also act as an adaptor in targeting mRNAs associated with phosphorylated UPF1 for degradation. SMG7 provides a link between the NMD pathway and mRNA degradation machinery by forming a complex with the proteins SMG5 and UPF1, interacting with them via its N-terminal domain, and targeting bound reporter transcripts for decay via its C-terminal domain. SMG7 contains a 14-3-3-like domain, and residues that bind phosphoserine-containing peptides in 14-3-3 proteins are conserved at the equivalent positions in SMG7. Alternative Name :
C1orf16; EST1 like protein C; EST1 telomerase component homolog C; EST1C; ever shorter telomeres 1C; FLJ23717; SGA56M; SMG 7; Swiss-Prot :
Q92540 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide SMG7 (K548). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS2112 SMG7 (K548) pAb.
SMG7 (K548) Peptide Applications :
Blocking Background :
In humans, NMD depends on RNA-dependent ATPase and 5' to 3' helicase UPF1, plus six other proteins designated SMG1, SMG5, SMG6, SMG7, UPF2 and UPF3. SMG5, SMG7 and UPF1 localize to cytoplasmic foci called P-bodies, while SMG5, SMG6 and SMG7 target UPF1 for dephosphorylation. SMG7 may also act as an adaptor in targeting mRNAs associated with phosphorylated UPF1 for degradation. SMG7 provides a link between the NMD pathway and mRNA degradation machinery by forming a complex with the proteins SMG5 and UPF1, interacting with them via its N-terminal domain, and targeting bound reporter transcripts for decay via its C-terminal domain. SMG7 contains a 14-3-3-like domain, and residues that bind phosphoserine-containing peptides in 14-3-3 proteins are conserved at the equivalent positions in SMG7. Alternative Name :
C1orf16; EST1 like protein C; EST1 telomerase component homolog C; EST1C; ever shorter telomeres 1C; FLJ23717; SGA56M; SMG 7; Swiss-Prot :
Q92540 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide SMG7 (K548). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS2112 SMG7 (K548) pAb.
Blocking peptide available as BS2112PP