BRMS-1 (E43) Peptide 
Datasheet
COA
MSDS
SHIP
Product Name :
BRMS-1 (E43) Peptide Applications :
Blocking Background :
Breast cancer metastasis-suppressor 1 (BRMS1) acts as a mediator of metastasis suppression in several types of cancer including ovarian, lung, bladder, and murine mammary. BRMS1 mRNA is expressed in various tissues, including ovary, prostate, testis, and colon, but the protein is primarily detected in term placenta. BRMS1 suppresses metastasis without inhibiting tumorigenicity by modifying several metastasis-associated phenotypes. BRMS1 may participate in transcriptional regulation by binding to the mSin3/histone deacetylase complex. The expression of BRMS1 in certain cells increases connexin Cx43 expression and reduces connexin Cx32 expression. This produces a gap junction that increases intercellular communication, similar to those found in normal breast tissue. BRMS1 is stabilized by Hsp90 and may inhibit NFκB activity. Alternative Name :
Breast cancer metastasis-suppressor 1; BRMS1; BRMS 1 Swiss-Prot :
Q9HCU9 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide BRMS-1 (E43). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS2144 BRMS-1 (E43) pAb.
BRMS-1 (E43) Peptide Applications :
Blocking Background :
Breast cancer metastasis-suppressor 1 (BRMS1) acts as a mediator of metastasis suppression in several types of cancer including ovarian, lung, bladder, and murine mammary. BRMS1 mRNA is expressed in various tissues, including ovary, prostate, testis, and colon, but the protein is primarily detected in term placenta. BRMS1 suppresses metastasis without inhibiting tumorigenicity by modifying several metastasis-associated phenotypes. BRMS1 may participate in transcriptional regulation by binding to the mSin3/histone deacetylase complex. The expression of BRMS1 in certain cells increases connexin Cx43 expression and reduces connexin Cx32 expression. This produces a gap junction that increases intercellular communication, similar to those found in normal breast tissue. BRMS1 is stabilized by Hsp90 and may inhibit NFκB activity. Alternative Name :
Breast cancer metastasis-suppressor 1; BRMS1; BRMS 1 Swiss-Prot :
Q9HCU9 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide BRMS-1 (E43). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS2144 BRMS-1 (E43) pAb.
Blocking peptide available as BS2144PP