PERK (R87) Peptide 
Datasheet
COA
MSDS
SHIP
Product Name :
PERK (R87) Peptide Applications :
Blocking Background :
An interferon-inducible, RNA-dependent protein serine /threonine kinase (PKR) has been described. PKR in earlier literature is variously known as DAI, dsJ, PI kinase, p65, p67 or TIK for the mouse kinase; and p68 or p69 for the human kinase. The PKR kinase substrate is the α subunit of protein synthesis initiation factor eIF-2. Phosphorylation of eIF-2α on serine-51 results in inhibition of translation. The serine /threonine kinase catalytic domains map to the carboxy terminal half of the protein while the RNA-binding domains are located in the amino terminal region. PERK is a type I transmembrane protein located in the endoplasmic reticulum (ER) that contains a kinase domain similar to the kinase domain of PKR. PERK is activated in response to ER stress and phosphorylates eIF-2α, thus inhibiting the translation of mRNA. Alternative Name :
EIF2AK3; DKFZP781H1925; EC 2.7.11.1; HSPEK; PEK; PERK; WRS Swiss-Prot :
Q9NZJ5 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide PERK (R87). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS2156 PERK (R87) pAb.
PERK (R87) Peptide Applications :
Blocking Background :
An interferon-inducible, RNA-dependent protein serine /threonine kinase (PKR) has been described. PKR in earlier literature is variously known as DAI, dsJ, PI kinase, p65, p67 or TIK for the mouse kinase; and p68 or p69 for the human kinase. The PKR kinase substrate is the α subunit of protein synthesis initiation factor eIF-2. Phosphorylation of eIF-2α on serine-51 results in inhibition of translation. The serine /threonine kinase catalytic domains map to the carboxy terminal half of the protein while the RNA-binding domains are located in the amino terminal region. PERK is a type I transmembrane protein located in the endoplasmic reticulum (ER) that contains a kinase domain similar to the kinase domain of PKR. PERK is activated in response to ER stress and phosphorylates eIF-2α, thus inhibiting the translation of mRNA. Alternative Name :
EIF2AK3; DKFZP781H1925; EC 2.7.11.1; HSPEK; PEK; PERK; WRS Swiss-Prot :
Q9NZJ5 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide PERK (R87). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS2156 PERK (R87) pAb.
Blocking peptide available as BS2156PP