RAGE (Q286) Peptide 
Datasheet
COA
MSDS
SHIP
Product Name :
RAGE (Q286) Peptide Applications :
Blocking Background :
Advanced glycosylation end products of proteins (AGEs) are nonenzymatically glycosylated proteins that are associated with a variety of conditions including diabetes and other vascular disorders, as well as amyloidosis. These proteins regulate cellular functions via specific cell surface acceptor molecules, such as RAGE (receptor for advanced glycosylation end products). RAGE is a type 1 membrane protein that is found on the surface of endothelial cells, mononuclear phagocytes and vascular smooth muscle cells. Binding of AGEs to RAGE results in the induction of cellular oxidant stress and activation of the transcription factor NFκB. Evidence suggests that the induction of oxidant stress results in the activation of an intracellular cascade involving p21 Ras and MAP kinase, which leads to activation of transcription. Alternative Name :
MAPK/MAK/MRK overlapping kinase; MOK protein kinase; Renal tumor antigen 1; Renal tumor antigen 1; Renal tumor antigen 1; RAGE; RAGE1 Swiss-Prot :
Q9UQ07 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide RAGE (Q286). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS2165 RAGE (Q286) pAb.
RAGE (Q286) Peptide Applications :
Blocking Background :
Advanced glycosylation end products of proteins (AGEs) are nonenzymatically glycosylated proteins that are associated with a variety of conditions including diabetes and other vascular disorders, as well as amyloidosis. These proteins regulate cellular functions via specific cell surface acceptor molecules, such as RAGE (receptor for advanced glycosylation end products). RAGE is a type 1 membrane protein that is found on the surface of endothelial cells, mononuclear phagocytes and vascular smooth muscle cells. Binding of AGEs to RAGE results in the induction of cellular oxidant stress and activation of the transcription factor NFκB. Evidence suggests that the induction of oxidant stress results in the activation of an intracellular cascade involving p21 Ras and MAP kinase, which leads to activation of transcription. Alternative Name :
MAPK/MAK/MRK overlapping kinase; MOK protein kinase; Renal tumor antigen 1; Renal tumor antigen 1; Renal tumor antigen 1; RAGE; RAGE1 Swiss-Prot :
Q9UQ07 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide RAGE (Q286). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS2165 RAGE (Q286) pAb.
Blocking peptide available as BS2165PP