14-3-3 β (Q69) Peptide 
Datasheet
COA
MSDS
SHIP
Product Name :
14-3-3 β (Q69) Peptide Applications :
Blocking Background :
14-3-3 proteins regulate many cellular processes relevant to cancer biology, notably apoptosis, mitogenic signaling and cell-cycle checkpoints. Seven isoforms comprise this family of signaling intermediates, denoted 14-3-3 β, γ, ε, ζ, η, θ and σ. 14-3-3 proteins form dimers that present two binding sites for ligand proteins, thereby bringing together two proteins that may not otherwise associate. These ligands largely share a 14-3-3 consensus binding motif and exhibit serine/threonine phosphorylation. 14-3-3 proteins function in broad regulation of these ligand proteins, by cytoplasmic sequestration, occupation of interaction domains and import/export sequences, prevention of degradation, activation/repression of enzymatic activity and facilitation of protein modification, and thus loss of expression contributes to a vast array of pathogenic cellular activities. Alternative Name :
14-3-3 protein beta/alpha; Protein 1054; Protein kinase C inhibitor protein 1; KCIP-1; YWHAB; 14-3-3β; 14-3-3 α; 14-3-3α; 1433B; 14-3-3 β/α; 14-3-3β/α; Swiss-Prot :
P31946 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide 14-3-3 β (Q69) . (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS2176 14-3-3 β (Q69) pAb .
14-3-3 β (Q69) Peptide Applications :
Blocking Background :
14-3-3 proteins regulate many cellular processes relevant to cancer biology, notably apoptosis, mitogenic signaling and cell-cycle checkpoints. Seven isoforms comprise this family of signaling intermediates, denoted 14-3-3 β, γ, ε, ζ, η, θ and σ. 14-3-3 proteins form dimers that present two binding sites for ligand proteins, thereby bringing together two proteins that may not otherwise associate. These ligands largely share a 14-3-3 consensus binding motif and exhibit serine/threonine phosphorylation. 14-3-3 proteins function in broad regulation of these ligand proteins, by cytoplasmic sequestration, occupation of interaction domains and import/export sequences, prevention of degradation, activation/repression of enzymatic activity and facilitation of protein modification, and thus loss of expression contributes to a vast array of pathogenic cellular activities. Alternative Name :
14-3-3 protein beta/alpha; Protein 1054; Protein kinase C inhibitor protein 1; KCIP-1; YWHAB; 14-3-3β; 14-3-3 α; 14-3-3α; 1433B; 14-3-3 β/α; 14-3-3β/α; Swiss-Prot :
P31946 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide 14-3-3 β (Q69) . (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS2176 14-3-3 β (Q69) pAb .
Blocking peptide available as BS2176PP