TFIIH p44 (T18) Peptide 
Datasheet
COA
MSDS
SHIP
Product Name :
TFIIH p44 (T18) Peptide Applications :
Blocking Background :
Initiation of transcription from protein-coding genes in eukaryotes is a complex process that requires RNA polymerase II, as well as families of basal transcription factors. Binding of the factor TFIID (TBP) to the TATA box is believed to be the first step in the formation of a multiprotein complex containing several additional factors, including TFIIA, TFIIB, TFIIE, TFIIF and TFII. TFIIH (or BTF2) is a multisubunit transcription/DNA repair factor that possesses several enzymatic activities. The core of TFIIH is composed of five subunits, designated p89 (XPB or ERCC3), p62, p52, p44 and p34. Additional subunits of the TFIIH complex are p80 (XPD or ERCC2) and the ternary kinase complex composed of Cdk7, cyclin H and MAT1. Both p89 and p80 have ATP-dependent helicase activity. The p62, p52 and p44 subunits have been shown to be involved in nucleotide excision repair. Alternative Name :
GTF2H2; BTF2; BTF2-P44; BTF2P44; MGC102806; T-BTF2P44; TFIIH Swiss-Prot :
Q13888 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide TFIIH p44 (T18). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS2306 TFIIH p44 (T18) pAb.
TFIIH p44 (T18) Peptide Applications :
Blocking Background :
Initiation of transcription from protein-coding genes in eukaryotes is a complex process that requires RNA polymerase II, as well as families of basal transcription factors. Binding of the factor TFIID (TBP) to the TATA box is believed to be the first step in the formation of a multiprotein complex containing several additional factors, including TFIIA, TFIIB, TFIIE, TFIIF and TFII. TFIIH (or BTF2) is a multisubunit transcription/DNA repair factor that possesses several enzymatic activities. The core of TFIIH is composed of five subunits, designated p89 (XPB or ERCC3), p62, p52, p44 and p34. Additional subunits of the TFIIH complex are p80 (XPD or ERCC2) and the ternary kinase complex composed of Cdk7, cyclin H and MAT1. Both p89 and p80 have ATP-dependent helicase activity. The p62, p52 and p44 subunits have been shown to be involved in nucleotide excision repair. Alternative Name :
GTF2H2; BTF2; BTF2-P44; BTF2P44; MGC102806; T-BTF2P44; TFIIH Swiss-Prot :
Q13888 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide TFIIH p44 (T18). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS2306 TFIIH p44 (T18) pAb.
Blocking peptide available as BS2306PP