MB67 (T102) Peptide 
Datasheet
COA
MSDS
SHIP
Product Name :
MB67 (T102) Peptide Applications :
Blocking Background :
This gene encodes a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists. Ligand binding results in translocation of this protein to the nucleus, where it activates or represses target gene transcription. These ligands include bilirubin, a variety of foreign compounds, steroid hormones, and prescription drugs. Multiple transcript variants encoding different isoforms have been found for this gene. Alternative Name :
Constitutive androstane receptor; CAR; Orphan nuclear receptor MB67; NR1I3; AA209988. AI551208. CAR. CAR1. CAR2. Care2. ESTM32. MB67. MGC107281. Mcar Swiss-Prot :
Q14994 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide MB67 (T102). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS2311 MB67 (T102) pAb.
MB67 (T102) Peptide Applications :
Blocking Background :
This gene encodes a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists. Ligand binding results in translocation of this protein to the nucleus, where it activates or represses target gene transcription. These ligands include bilirubin, a variety of foreign compounds, steroid hormones, and prescription drugs. Multiple transcript variants encoding different isoforms have been found for this gene. Alternative Name :
Constitutive androstane receptor; CAR; Orphan nuclear receptor MB67; NR1I3; AA209988. AI551208. CAR. CAR1. CAR2. Care2. ESTM32. MB67. MGC107281. Mcar Swiss-Prot :
Q14994 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide MB67 (T102). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS2311 MB67 (T102) pAb.
Blocking peptide available as BS2311PP