AIM2 (A78) Peptide 
Datasheet
COA
MSDS
SHIP
Product Name :
AIM2 (A78) Peptide Applications :
Blocking Background :
Interferon-inducible protein AIM2 (absent in melanoma 2) is a 343 amino acid protein belonging to the HIN-200 family. Induced by IFN-γ, AIM2 is thought to act as a tumor suppressor by repressing NFκB transcriptional activity. Localized to the nucleus, AIM2 contains one DAPIN domain and one HIN-200 domain. The DAPIN domain is composed mostly of α-helixes and is a protein-protein interaction domain capable of binding other DAPIN domains. The HIN-200 domain has been shown to bind directly to DNA, which, along with the binding of another protein ASC, results in the activation of caspase-1. AIM2 is present as a homodimer and is expressed highly in small intestine, testis, peripheral blood leukocytes and spleen. Defects in AIM2 are believed to be a cause of microsatellite unstable colon cancers. Alternative Name :
Absent in melanoma 2; AIM 2; Aim2; AIM2; Interferon-inducible protein AIM2; OTTHUMP00000035296; PYHIN4; Swiss-Prot :
O14862 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide AIM2 (A78). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS2393 AIM2 (A78) pAb.
AIM2 (A78) Peptide Applications :
Blocking Background :
Interferon-inducible protein AIM2 (absent in melanoma 2) is a 343 amino acid protein belonging to the HIN-200 family. Induced by IFN-γ, AIM2 is thought to act as a tumor suppressor by repressing NFκB transcriptional activity. Localized to the nucleus, AIM2 contains one DAPIN domain and one HIN-200 domain. The DAPIN domain is composed mostly of α-helixes and is a protein-protein interaction domain capable of binding other DAPIN domains. The HIN-200 domain has been shown to bind directly to DNA, which, along with the binding of another protein ASC, results in the activation of caspase-1. AIM2 is present as a homodimer and is expressed highly in small intestine, testis, peripheral blood leukocytes and spleen. Defects in AIM2 are believed to be a cause of microsatellite unstable colon cancers. Alternative Name :
Absent in melanoma 2; AIM 2; Aim2; AIM2; Interferon-inducible protein AIM2; OTTHUMP00000035296; PYHIN4; Swiss-Prot :
O14862 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide AIM2 (A78). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS2393 AIM2 (A78) pAb.
Blocking peptide available as BS2393PP