MSH6 / GTBP (E371) Peptide 
Datasheet
COA
MSDS
SHIP
Product Name :
MSH6 / GTBP (E371) Peptide Applications :
Blocking Background :
The finding that mutations in DNA mismatch repair genes are associated with hereditary nonpolyposis colorectal cancer (HNPCC) has resulted in considerable interest in the understanding of the mechanism of DNA mismatch repair. Initially, inherited mutations in the MSH2 and MLH1 homologs of the bacterial DNA mismatch repair genes MutS and MutL were demonstrated at high frequency in HNPCC and were shown to be associated with microsatellite instability. A member of the mismatch repair family, GTBP (also designated MSH6), is a 160 kDa MSH2-related protein that binds to DNA containing G/T mismatches. Findings suggest that the mismatch-binding factor in human cells is composed of a heterodimer of GTBP and MSH2. Alternative Name :
MSH6; GTBP; GTMBP; HNPCC5; HSAP; P160 Swiss-Prot :
P52701 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide MSH6 / GTBP (E371). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS2420 MSH6 / GTBP (E371) pAb.
MSH6 / GTBP (E371) Peptide Applications :
Blocking Background :
The finding that mutations in DNA mismatch repair genes are associated with hereditary nonpolyposis colorectal cancer (HNPCC) has resulted in considerable interest in the understanding of the mechanism of DNA mismatch repair. Initially, inherited mutations in the MSH2 and MLH1 homologs of the bacterial DNA mismatch repair genes MutS and MutL were demonstrated at high frequency in HNPCC and were shown to be associated with microsatellite instability. A member of the mismatch repair family, GTBP (also designated MSH6), is a 160 kDa MSH2-related protein that binds to DNA containing G/T mismatches. Findings suggest that the mismatch-binding factor in human cells is composed of a heterodimer of GTBP and MSH2. Alternative Name :
MSH6; GTBP; GTMBP; HNPCC5; HSAP; P160 Swiss-Prot :
P52701 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide MSH6 / GTBP (E371). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS2420 MSH6 / GTBP (E371) pAb.
Blocking peptide available as BS2420PP