Siah-2 (E266) Peptide 
Datasheet
COA
MSDS
SHIP
Product Name :
Siah-2 (E266) Peptide Applications :
Blocking Background :
SIAH-2 (seven in absentia homolog 2) is an E3 ligase that catalyzes ubiquitination and proteasome-mediated degradation of protein substrates. SIAH-2 encodes a 324 amino acid protein that shares 77% identity with human SIAH-1 and 68% identity with the Drosophila sina (seven in absentia) gene, on which development of the Drosophila R7 photoreceptor is dependent. SIAH-2 targets TRAF2 (which regulates cell responses to stress and cytokines through the regulation of key stress-signaling cascades) for degradation under stress conditions such as hypoxia. It targets HIF-1α prolyl hydroxylase 3 (PHD3) for degradation upon exposure to hypoxic conditions, which coincides with an increase in SIAH-2 transcription. SIAH-2 can decrease TNF-α-dependent induction of JNK activity and transcriptional activation of NFκB. SIAH-2 null mice subjected to hypoxia display an impaired respiratory response and reduced levels of hemoglobin. Alternative Name :
SIAH1; HUMSIAH. Siah-1. Siah-1a. hSIAH1 Swiss-Prot :
O43255 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide Siah-2 (E266). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS2425 Siah-2 (E266) pAb.
Siah-2 (E266) Peptide Applications :
Blocking Background :
SIAH-2 (seven in absentia homolog 2) is an E3 ligase that catalyzes ubiquitination and proteasome-mediated degradation of protein substrates. SIAH-2 encodes a 324 amino acid protein that shares 77% identity with human SIAH-1 and 68% identity with the Drosophila sina (seven in absentia) gene, on which development of the Drosophila R7 photoreceptor is dependent. SIAH-2 targets TRAF2 (which regulates cell responses to stress and cytokines through the regulation of key stress-signaling cascades) for degradation under stress conditions such as hypoxia. It targets HIF-1α prolyl hydroxylase 3 (PHD3) for degradation upon exposure to hypoxic conditions, which coincides with an increase in SIAH-2 transcription. SIAH-2 can decrease TNF-α-dependent induction of JNK activity and transcriptional activation of NFκB. SIAH-2 null mice subjected to hypoxia display an impaired respiratory response and reduced levels of hemoglobin. Alternative Name :
SIAH1; HUMSIAH. Siah-1. Siah-1a. hSIAH1 Swiss-Prot :
O43255 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide Siah-2 (E266). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS2425 Siah-2 (E266) pAb.
Blocking peptide available as BS2425PP