ERβ (E101) Peptide 
Datasheet
COA
MSDS
SHIP
Product Name :
ERβ (E101) Peptide Applications :
Blocking Background :
The discovery of a second estrogen receptor has redefined the estrogen signaling pathway and may have broad implications on estrogen-responsive tissues.1 The new estrogen receptor, named estrogen receptor-beta (ERβ), is preferentially expressed in the prostate and maintains some characteristics that are different from ERα.2 The rat tissue distribution and/or the relative level of ERα and ERβ expression seems to be quite different, i.e., moderate to high expression in uterus, testis, pituitary, ovary, kidney, epididymis, and adrenal for ERα and prostate, ovary, lung, bladder, brain, bone, uterus, and testis for ERβ. Within the same organ it often appears that the ER subtypes are expressed in different cell types, supporting the hypothesis that the ER's may have different biological functions. The discovery of ERβ suggests the existence of two previously unrecognized pathways of estrogen signaling, via the ERβ subtype in tissues exclusively expressing this subtype and via the formation of heterodimers in tissues expressing both ER subtypes.The existence of two ER subtypes, their differential expression pattern, and different actions on certain response elements could provide explanations for the striking species-, cell-, and promoter-specific actions of estrogens and antiestrogens.3 Both estrogen receptors appear to be involved in a multitude of regulatory events. Alternative Name :
ESR2; ER-BETA; ERB; ESR-BETA; ESRB; ESTRB; NR3A2 Swiss-Prot :
Q92731 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide ERβ (E101). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS2429 ERβ (E101) pAb.
ERβ (E101) Peptide Applications :
Blocking Background :
The discovery of a second estrogen receptor has redefined the estrogen signaling pathway and may have broad implications on estrogen-responsive tissues.1 The new estrogen receptor, named estrogen receptor-beta (ERβ), is preferentially expressed in the prostate and maintains some characteristics that are different from ERα.2 The rat tissue distribution and/or the relative level of ERα and ERβ expression seems to be quite different, i.e., moderate to high expression in uterus, testis, pituitary, ovary, kidney, epididymis, and adrenal for ERα and prostate, ovary, lung, bladder, brain, bone, uterus, and testis for ERβ. Within the same organ it often appears that the ER subtypes are expressed in different cell types, supporting the hypothesis that the ER's may have different biological functions. The discovery of ERβ suggests the existence of two previously unrecognized pathways of estrogen signaling, via the ERβ subtype in tissues exclusively expressing this subtype and via the formation of heterodimers in tissues expressing both ER subtypes.The existence of two ER subtypes, their differential expression pattern, and different actions on certain response elements could provide explanations for the striking species-, cell-, and promoter-specific actions of estrogens and antiestrogens.3 Both estrogen receptors appear to be involved in a multitude of regulatory events. Alternative Name :
ESR2; ER-BETA; ERB; ESR-BETA; ESRB; ESTRB; NR3A2 Swiss-Prot :
Q92731 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide ERβ (E101). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS2429 ERβ (E101) pAb.
Blocking peptide available as BS2429PP