ERK8 (D171) Peptide 
Datasheet
COA
MSDS
SHIP
Product Name :
ERK8 (D171) Peptide Applications :
Blocking Background :
The ERKs are a subfamily of the MAPKs that have been implicated in cell growth and differentiation. Extracellular signal-regulated kinase 8 (Erk8) is a large MAP kinase whose activity is controlled by serum and the c-Src non-receptor tyrosine kinase. ERK8 down-regulates transactivation of the glucocorticoid receptor through Hic-5 and can negatively regulate transcriptional co-activation of androgen receptor and GRalpha by Hic-5 in a kinase-independent manner, suggesting a broader role for ERK8 in the regulation of nuclear receptors beyond estrogen receptor alpha. Erk8 is a novel effector of RET/PTC3 and, therefore, RET biological functions. Alternative Name :
Extracellular signal-regulated kinase 8; MAPK15; Mitogen-activated protein kinase 15 Swiss-Prot :
Q8TD08 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide ERK8 (D171). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS2438 ERK8 (D171) pAb.
ERK8 (D171) Peptide Applications :
Blocking Background :
The ERKs are a subfamily of the MAPKs that have been implicated in cell growth and differentiation. Extracellular signal-regulated kinase 8 (Erk8) is a large MAP kinase whose activity is controlled by serum and the c-Src non-receptor tyrosine kinase. ERK8 down-regulates transactivation of the glucocorticoid receptor through Hic-5 and can negatively regulate transcriptional co-activation of androgen receptor and GRalpha by Hic-5 in a kinase-independent manner, suggesting a broader role for ERK8 in the regulation of nuclear receptors beyond estrogen receptor alpha. Erk8 is a novel effector of RET/PTC3 and, therefore, RET biological functions. Alternative Name :
Extracellular signal-regulated kinase 8; MAPK15; Mitogen-activated protein kinase 15 Swiss-Prot :
Q8TD08 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide ERK8 (D171). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS2438 ERK8 (D171) pAb.
Blocking peptide available as BS2438PP