CIITA (T740) Peptide 
Datasheet
COA
MSDS
SHIP
Product Name :
CIITA (T740) Peptide Applications :
Blocking Background :
The transactivator CIITA regulates basal and interferon-induced expression of MHC class II genes. CIITA restores expression of all MHC II gene expression in mutant cells and corrects regulatory defects of those genes. Activation is via the proximal promoter. No DNA binding of in vitro translated CIITA was detected. CIITA may act in a coactivator-like fashion through protein-protein interactions by contacting factors binding to the proximal MHC class II promoter, to elements of the transcription machinery, or both. Alternatively it may activate HLA class II transcription by modifying proteins that bind to the MHC class II promoter. Alternative Name :
MHC class II transactivator; CIITA; C2TA; MHC2TA Swiss-Prot :
P33076 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide CIITA (T740). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS2471 CIITA (T740) pAb.
CIITA (T740) Peptide Applications :
Blocking Background :
The transactivator CIITA regulates basal and interferon-induced expression of MHC class II genes. CIITA restores expression of all MHC II gene expression in mutant cells and corrects regulatory defects of those genes. Activation is via the proximal promoter. No DNA binding of in vitro translated CIITA was detected. CIITA may act in a coactivator-like fashion through protein-protein interactions by contacting factors binding to the proximal MHC class II promoter, to elements of the transcription machinery, or both. Alternatively it may activate HLA class II transcription by modifying proteins that bind to the MHC class II promoter. Alternative Name :
MHC class II transactivator; CIITA; C2TA; MHC2TA Swiss-Prot :
P33076 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide CIITA (T740). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS2471 CIITA (T740) pAb.
Blocking peptide available as BS2471PP