DGK-θ (S725) Peptide 
Datasheet
COA
MSDS
SHIP
Product Name :
DGK-θ (S725) Peptide Applications :
Blocking Background :
Diacylglycerol (DAG) is a fundamental lipid second messenger that is produced in the nucleus. The accumulation of DAG in the nucleus is important for the regulation of cell growth and differentiation. Diacylglycerol kinases (DGKs) convert DAG to phosphatidic acid, thereby terminating diacylglycerol signaling, which results in the reduction of protein kinase C activity and cell cycle progression of T lymphocytes. Diacylglycerol kinases are divided into five subtypes, Type I-Type V. DGK-θ is a Type V DGK, and localizes mainly to the nucleus of various cell lines, such as MDA-MB-453, MCF-7, PC12 and HeLa. Nuclear DGK-θ co-localizes with phosphatidylinositol 4,5-bisphosphate (PIP(2)). DGK-θ is the isoform responsive to α-Thrombin stimulation. Alternative Name :
DGKQ; DAGK4; Diacylglycerol kinase theta; DGK-theta Swiss-Prot :
P52824 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide DGK-θ (S725). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS2479 DGK-θ (S725) pAb.
DGK-θ (S725) Peptide Applications :
Blocking Background :
Diacylglycerol (DAG) is a fundamental lipid second messenger that is produced in the nucleus. The accumulation of DAG in the nucleus is important for the regulation of cell growth and differentiation. Diacylglycerol kinases (DGKs) convert DAG to phosphatidic acid, thereby terminating diacylglycerol signaling, which results in the reduction of protein kinase C activity and cell cycle progression of T lymphocytes. Diacylglycerol kinases are divided into five subtypes, Type I-Type V. DGK-θ is a Type V DGK, and localizes mainly to the nucleus of various cell lines, such as MDA-MB-453, MCF-7, PC12 and HeLa. Nuclear DGK-θ co-localizes with phosphatidylinositol 4,5-bisphosphate (PIP(2)). DGK-θ is the isoform responsive to α-Thrombin stimulation. Alternative Name :
DGKQ; DAGK4; Diacylglycerol kinase theta; DGK-theta Swiss-Prot :
P52824 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide DGK-θ (S725). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS2479 DGK-θ (S725) pAb.
Blocking peptide available as BS2479PP