Dio-1 (S186) Peptide 
Datasheet
COA
MSDS
SHIP
Product Name :
Dio-1 (S186) Peptide Applications :
Blocking Background :
Dio-1 (Death Inducer-Obliterator-1) is a putative transcription factor that contains two zinc finger motifs. Dio-1 translocates to the nucleus, and activates apoptosis during limb development. Programmed cell death, a highly regulated form of apoptosis, plays an important role in determining the amount of tissue, the shape, and the definition of each digit during limb development. Dio-1 expression is upregulated when an apoptotic signal is detected, and subsequently apoptosis is induced. This process is similar to the expression of NFκB and NGF in response to external signals. Dio-1 expression is suppressed by caspase inhibitors and Bcl-2 expression. This supports the theory that Dio-1 functions in the onset of programmed cell death. Alternative Name :
DIDO1; BYE1; C20ORF158; DATF-1; DATF1; DIDO2; DIDO3; DIO-1; DIO1; DJ885L7.8; DKFZP434P1115; FLJ11265; HDIDO1; KIAA0333; MGC16140 Swiss-Prot :
Q9BTC0 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide Dio-1 (S186). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS2533 Dio-1 (S186) pAb.
Dio-1 (S186) Peptide Applications :
Blocking Background :
Dio-1 (Death Inducer-Obliterator-1) is a putative transcription factor that contains two zinc finger motifs. Dio-1 translocates to the nucleus, and activates apoptosis during limb development. Programmed cell death, a highly regulated form of apoptosis, plays an important role in determining the amount of tissue, the shape, and the definition of each digit during limb development. Dio-1 expression is upregulated when an apoptotic signal is detected, and subsequently apoptosis is induced. This process is similar to the expression of NFκB and NGF in response to external signals. Dio-1 expression is suppressed by caspase inhibitors and Bcl-2 expression. This supports the theory that Dio-1 functions in the onset of programmed cell death. Alternative Name :
DIDO1; BYE1; C20ORF158; DATF-1; DATF1; DIDO2; DIDO3; DIO-1; DIO1; DJ885L7.8; DKFZP434P1115; FLJ11265; HDIDO1; KIAA0333; MGC16140 Swiss-Prot :
Q9BTC0 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide Dio-1 (S186). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS2533 Dio-1 (S186) pAb.
Blocking peptide available as BS2533PP