CLK1 (R126) Peptide 
Datasheet
COA
MSDS
SHIP
Product Name :
CLK1 (R126) Peptide Applications :
Blocking Background :
The CDC-like kinase 1 (CLK1) dually phosphorylates serine and arginine rich proteins of the spliceosomal complex, which constitutes a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Specifically, CLK1 may mediate the release of specific proteins from nuclear storage sites. Expression of CLK1 may be very low due to a premature stop codon in the mRNA, which leads to nonsense-mediated mRNA decay. CLK1 activity is positively regulated by phosphorylation on either tyrosine residues or serine/ threonine residues, and is negatively regulated by steric constraints mediated by the N-terminal domain, and also by phosphorylation on a subset of serine/threonine residues within the catalytic domain. Alternative Name :
CDC like kinase 1; CDC-like kinase 1; CDC28/CDC2 like kinase; CLK; CLK/STY; Clk1; CLK1; Dual specificity protein kinase CLK1; Protein tyrosine kinase STY; STY; Swiss-Prot :
P49759 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide CLK1 (R126). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS2556 CLK1 (R126) pAb.
CLK1 (R126) Peptide Applications :
Blocking Background :
The CDC-like kinase 1 (CLK1) dually phosphorylates serine and arginine rich proteins of the spliceosomal complex, which constitutes a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Specifically, CLK1 may mediate the release of specific proteins from nuclear storage sites. Expression of CLK1 may be very low due to a premature stop codon in the mRNA, which leads to nonsense-mediated mRNA decay. CLK1 activity is positively regulated by phosphorylation on either tyrosine residues or serine/ threonine residues, and is negatively regulated by steric constraints mediated by the N-terminal domain, and also by phosphorylation on a subset of serine/threonine residues within the catalytic domain. Alternative Name :
CDC like kinase 1; CDC-like kinase 1; CDC28/CDC2 like kinase; CLK; CLK/STY; Clk1; CLK1; Dual specificity protein kinase CLK1; Protein tyrosine kinase STY; STY; Swiss-Prot :
P49759 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide CLK1 (R126). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS2556 CLK1 (R126) pAb.
Blocking peptide available as BS2556PP