Matriptase (K21) Peptide 
Datasheet
COA
MSDS
SHIP
Product Name :
Matriptase (K21) Peptide Applications :
Blocking Background :
Matriptase (also known as MT-SP1, ST14, prostamin and epithin in mouse) is a tumor-associated type II transmembrane serine protease that is highly expressed in many human cancer-derived cell lines and is implicated in extracellular matrix re-modeling, tumor growth, and metastasis. Matriptase performs pleiotropic functions in the development of the epidermis, hair follicles, and cellular immune system. Sphingosine 1-phosphate (S1P, SPP), present in serum-derived lipoproteins, activates matriptase while matriptase activates both urokinase-type plasminogen activator and hepatocyte growth factor (HGF). Hepatocyte growth factor activator inhibitor type 1 (HAI-1) is a Kunitz-type serine protease inhibitor identified as a strong inhibitor of matriptase and HGF. Advanced-stage ovarian tumors that express matriptase are more likely to do so in the absence of its inhibitor, HAI-1, indicating that an imbalance in the matriptase: HAI-1 ratio could be important in the development of advanced disease. Alternative Name :
ST14; EC 3.4.21.-; HAI; MATRIPTASE; MT-SP1; MTSP-1; MTSP1; PROSTAMIN; PRSS14; SNC19; TADG-15; TADG15 Swiss-Prot :
Q9Y5Y6 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide Matriptase (K21). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS2574 Matriptase (K21) pAb.
Matriptase (K21) Peptide Applications :
Blocking Background :
Matriptase (also known as MT-SP1, ST14, prostamin and epithin in mouse) is a tumor-associated type II transmembrane serine protease that is highly expressed in many human cancer-derived cell lines and is implicated in extracellular matrix re-modeling, tumor growth, and metastasis. Matriptase performs pleiotropic functions in the development of the epidermis, hair follicles, and cellular immune system. Sphingosine 1-phosphate (S1P, SPP), present in serum-derived lipoproteins, activates matriptase while matriptase activates both urokinase-type plasminogen activator and hepatocyte growth factor (HGF). Hepatocyte growth factor activator inhibitor type 1 (HAI-1) is a Kunitz-type serine protease inhibitor identified as a strong inhibitor of matriptase and HGF. Advanced-stage ovarian tumors that express matriptase are more likely to do so in the absence of its inhibitor, HAI-1, indicating that an imbalance in the matriptase: HAI-1 ratio could be important in the development of advanced disease. Alternative Name :
ST14; EC 3.4.21.-; HAI; MATRIPTASE; MT-SP1; MTSP-1; MTSP1; PROSTAMIN; PRSS14; SNC19; TADG-15; TADG15 Swiss-Prot :
Q9Y5Y6 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide Matriptase (K21). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS2574 Matriptase (K21) pAb.
Blocking peptide available as BS2574PP