Topo IIα (E1102) Peptide 
Datasheet
COA
MSDS
SHIP
Product Name :
Topo IIα (E1102) Peptide Applications :
Blocking Background :
DNA topoisomerase I and II (Topo I and Topo II) are nuclear enzymes that regulate the topological structure of DNA in eukaryotic cells by transiently breaking and rejoining DNA strands. Eukaryotic topoisomerases are capable of relaxing both positive and negative supercoils, whereas prokaryotic topoisomerases relax only negative supercoils. DNA topoisomerases play a role in DNA replication, recombination and transcription and have been identified as targets of numerous anticancer drugs. Topo I, a ubiquitously expressed, soluble enzyme, acts by introducing a transient break in one strand of DNA, while Topo II acts by making a transient double-strand break. Topo II is encoded by two different genes to generate two distinct isoforms that are designated Topo IIα and Topo IIβ. Alternative Name :
Topoisomerase II alpha 170 kDa; Topo II alpha; Topoisomerase DNA II alpha 170kDa; TopII alpha; TP2A; TOP2A; TOP2; TOP 2A; EC 5.99.1.3; DNA topoisomerase II alpha isozyme; DNA topoisomerase II 170 kD; DNA topoisomerase 2 alpha; DNA Topoisomerase2 Swiss-Prot :
P11388 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide Topo IIα (E1102). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS2643 Topo IIα (E1102) pAb.
Topo IIα (E1102) Peptide Applications :
Blocking Background :
DNA topoisomerase I and II (Topo I and Topo II) are nuclear enzymes that regulate the topological structure of DNA in eukaryotic cells by transiently breaking and rejoining DNA strands. Eukaryotic topoisomerases are capable of relaxing both positive and negative supercoils, whereas prokaryotic topoisomerases relax only negative supercoils. DNA topoisomerases play a role in DNA replication, recombination and transcription and have been identified as targets of numerous anticancer drugs. Topo I, a ubiquitously expressed, soluble enzyme, acts by introducing a transient break in one strand of DNA, while Topo II acts by making a transient double-strand break. Topo II is encoded by two different genes to generate two distinct isoforms that are designated Topo IIα and Topo IIβ. Alternative Name :
Topoisomerase II alpha 170 kDa; Topo II alpha; Topoisomerase DNA II alpha 170kDa; TopII alpha; TP2A; TOP2A; TOP2; TOP 2A; EC 5.99.1.3; DNA topoisomerase II alpha isozyme; DNA topoisomerase II 170 kD; DNA topoisomerase 2 alpha; DNA Topoisomerase2 Swiss-Prot :
P11388 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide Topo IIα (E1102). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS2643 Topo IIα (E1102) pAb.
Blocking peptide available as BS2643PP