ERK3 (D475) Peptide 
Datasheet
COA
MSDS
SHIP
Product Name :
ERK3 (D475) Peptide Applications :
Blocking Background :
Mitogen-activated protein kinase (MAPK) signaling pathways involve closely related MAP kinases, including extracellular-signal-related kinase 3 (ERK 3, also designated PRKM6 and p97MAPK). Serum, growth factors and phorbol esters can initiate ERK 3 signaling pathways. Despite lacking a definitive nuclear localization sequence, ERK 3 constitutively localizes to the nucleus upon activation. p38 pathway activation-dependent upregulation of ERK 3 is independent of the status of p53, Bcl2 and caspase 3 during cell stress and damage induced by proteasome inhibition, suggesting ERK 3 in part mediates intracellular defense or cell rescue. The human ERK3 gene maps to chromosome 15q21 and encodes a 721 amino acid protein. Alternative Name :
MAPK6; DKFZP686F03189; EC 2.7.11.24; ERK-3; ERK3; HST17250; P97MAPK; PRKM6 Swiss-Prot :
Q16659 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide ERK3 (D475). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS2662 ERK3 (D475) pAb.
ERK3 (D475) Peptide Applications :
Blocking Background :
Mitogen-activated protein kinase (MAPK) signaling pathways involve closely related MAP kinases, including extracellular-signal-related kinase 3 (ERK 3, also designated PRKM6 and p97MAPK). Serum, growth factors and phorbol esters can initiate ERK 3 signaling pathways. Despite lacking a definitive nuclear localization sequence, ERK 3 constitutively localizes to the nucleus upon activation. p38 pathway activation-dependent upregulation of ERK 3 is independent of the status of p53, Bcl2 and caspase 3 during cell stress and damage induced by proteasome inhibition, suggesting ERK 3 in part mediates intracellular defense or cell rescue. The human ERK3 gene maps to chromosome 15q21 and encodes a 721 amino acid protein. Alternative Name :
MAPK6; DKFZP686F03189; EC 2.7.11.24; ERK-3; ERK3; HST17250; P97MAPK; PRKM6 Swiss-Prot :
Q16659 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide ERK3 (D475). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS2662 ERK3 (D475) pAb.
Blocking peptide available as BS2662PP