Neurofibromin (R1575) Peptide 
Datasheet
COA
MSDS
SHIP
Product Name :
Neurofibromin (R1575) Peptide Applications :
Blocking Background :
Neurofibromatosis type 1 (NF1), or von Reckinghausen neurofibromatosis, is one of the most common autosomal dominant disorders in humans. Early linkage analysis mapped the NF1 gene to chromosome 17. The predicted NF1 transcript encodes a 2818 amino acid protein designated NF1GRP. By sequence analysis, similarity has been demonstrated within a small region of NF1GRP and members of the Ras GAP gene family. Functionally, NF1GRP was shown by biochemical analysis involving RAS-GAP hydrolysis and functional complementation in yeast to further resemble GAP protein. The NF1 protein is expressed at relatively constant levels in a broad range of cell lines and tissues including brain, lung, liver, kidney, spleen, muscle and colon.Although little is known regarding the function of NF1GRP, the homology with the catalytic domain of proteins with GTPase activity suggests that the NF1GRP may also interact in vivo with Ras proteins. Alternative Name :
Neurofibromin; Neurofibromatosis-related protein NF-1; Neurofibromin; 4763; NF1; 162200; P21359; DKFZp686J1293; NFNS; VRNF; WSS; Swiss-Prot :
P21359 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide Neurofibromin (R1575). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS2687 Neurofibromin (R1575) pAb.
Neurofibromin (R1575) Peptide Applications :
Blocking Background :
Neurofibromatosis type 1 (NF1), or von Reckinghausen neurofibromatosis, is one of the most common autosomal dominant disorders in humans. Early linkage analysis mapped the NF1 gene to chromosome 17. The predicted NF1 transcript encodes a 2818 amino acid protein designated NF1GRP. By sequence analysis, similarity has been demonstrated within a small region of NF1GRP and members of the Ras GAP gene family. Functionally, NF1GRP was shown by biochemical analysis involving RAS-GAP hydrolysis and functional complementation in yeast to further resemble GAP protein. The NF1 protein is expressed at relatively constant levels in a broad range of cell lines and tissues including brain, lung, liver, kidney, spleen, muscle and colon.Although little is known regarding the function of NF1GRP, the homology with the catalytic domain of proteins with GTPase activity suggests that the NF1GRP may also interact in vivo with Ras proteins. Alternative Name :
Neurofibromin; Neurofibromatosis-related protein NF-1; Neurofibromin; 4763; NF1; 162200; P21359; DKFZp686J1293; NFNS; VRNF; WSS; Swiss-Prot :
P21359 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide Neurofibromin (R1575). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS2687 Neurofibromin (R1575) pAb.
Blocking peptide available as BS2687PP