IP6K2 (L188) Peptide 
Datasheet
COA
MSDS
SHIP
Product Name :
IP6K2 (L188) Peptide Applications :
Blocking Background :
The members of the inositol hexakisphosphate kinase family, IP6K1 and IP6K2, have a high affinity and selectivity for inositol hexakisphosphate (InsP6) as a substrate. IP6K1 and IP6K2 (also designated PiUS) convert InsP6 to PP-InsP5. However, neither kinase demonstrates any catalytic activity with other inositol pyrophosphates. The presence of InsP6, which inhibits serine/threonine protein phosphatases, increases the influx of calcium across the plasma membrane and implies that it may mediate the regulation of insulin exocytosis. IP6K1 was purified as a 54 kDa protein in rat brain extracts. By homology, IP6K1 and IP6K2 were characterized in mouse as a 50 kDa and 49 kDa protein, respectively. IP6K1 displays ATP synthase activity by transferring a phosphate from PP-InsP5 to ADP, which suggests a role for the IP6 kinases as high energy phosphate donors. Alternative Name :
Inositol hexakisphosphate kinase 2; InsP6 kinase 2; P(i)-uptake stimulator; PiUS; IP6K2; IHPK2; TCCCIA00113 Swiss-Prot :
Q9UHH9 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide IP6K2 (L188). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS2759 IP6K2 (L188) pAb.
IP6K2 (L188) Peptide Applications :
Blocking Background :
The members of the inositol hexakisphosphate kinase family, IP6K1 and IP6K2, have a high affinity and selectivity for inositol hexakisphosphate (InsP6) as a substrate. IP6K1 and IP6K2 (also designated PiUS) convert InsP6 to PP-InsP5. However, neither kinase demonstrates any catalytic activity with other inositol pyrophosphates. The presence of InsP6, which inhibits serine/threonine protein phosphatases, increases the influx of calcium across the plasma membrane and implies that it may mediate the regulation of insulin exocytosis. IP6K1 was purified as a 54 kDa protein in rat brain extracts. By homology, IP6K1 and IP6K2 were characterized in mouse as a 50 kDa and 49 kDa protein, respectively. IP6K1 displays ATP synthase activity by transferring a phosphate from PP-InsP5 to ADP, which suggests a role for the IP6 kinases as high energy phosphate donors. Alternative Name :
Inositol hexakisphosphate kinase 2; InsP6 kinase 2; P(i)-uptake stimulator; PiUS; IP6K2; IHPK2; TCCCIA00113 Swiss-Prot :
Q9UHH9 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide IP6K2 (L188). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS2759 IP6K2 (L188) pAb.
Blocking peptide available as BS2759PP