MLH3 (R546) Peptide 
Datasheet
COA
MSDS
SHIP
Product Name :
MLH3 (R546) Peptide Applications :
Blocking Background :
DNA mismatch repair (MMR) is essential for maintaining the integrity of the genome during replication. This process is highly conserved across bacterial and eukaryotic systems, as many of the genes expressed in bacteria are closely related to the yeast and mammalian homologs. In bacteria two proteins, MutS and MutL, form homodimeric complexes that are responsible for recognizing and facilitating MMR. Human homologs of these proteins include MSH2 and MSH3 (MutS homolog 2 and 3), and the corresponding human homologs of MutL are MLH1, PMS1, PMS2 and MLH3. MSH2 and MSH3 form heterodimers that cooperatively mediate MMR. MLH3 preferentially dimerizes with MLH1 to repair DNA mismatches and restore the stability to the genome. Mutations in the genes encoding MSH2 and MLH1 induce microsatellite instablitiy of the DNA. These mutations are associated with the occurrence of hereditary nonpolyposis colorectal cancer (HNPCC) and are a common feature in the progression of many other cancers. Alternative Name :
MLH1; COCA2; FCC2; HMLH1; HNPCC; HNPCC2; MGC5172 Swiss-Prot :
Q9UHC1 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide MLH3 (R546). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS2762 MLH3 (R546) pAb.
MLH3 (R546) Peptide Applications :
Blocking Background :
DNA mismatch repair (MMR) is essential for maintaining the integrity of the genome during replication. This process is highly conserved across bacterial and eukaryotic systems, as many of the genes expressed in bacteria are closely related to the yeast and mammalian homologs. In bacteria two proteins, MutS and MutL, form homodimeric complexes that are responsible for recognizing and facilitating MMR. Human homologs of these proteins include MSH2 and MSH3 (MutS homolog 2 and 3), and the corresponding human homologs of MutL are MLH1, PMS1, PMS2 and MLH3. MSH2 and MSH3 form heterodimers that cooperatively mediate MMR. MLH3 preferentially dimerizes with MLH1 to repair DNA mismatches and restore the stability to the genome. Mutations in the genes encoding MSH2 and MLH1 induce microsatellite instablitiy of the DNA. These mutations are associated with the occurrence of hereditary nonpolyposis colorectal cancer (HNPCC) and are a common feature in the progression of many other cancers. Alternative Name :
MLH1; COCA2; FCC2; HMLH1; HNPCC; HNPCC2; MGC5172 Swiss-Prot :
Q9UHC1 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide MLH3 (R546). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS2762 MLH3 (R546) pAb.
Blocking peptide available as BS2762PP