Frizzled-9 (L591) Peptide 
Datasheet
COA
MSDS
SHIP
Product Name :
Frizzled-9 (L591) Peptide Applications :
Blocking Background :
The frizzled gene, originally identified in Drosophila melanogaster, is involved in the development of tissue polarity. The mammalian homolog of frizzled as well as several secreted mammalian frizzled-related proteins (FRPs) have been described. The frizzled proteins contain seven transmembrane domains, a cysteine-rich domain in the extracellular region and a carboxy terminal Ser/Thr-xxx-Val motif. They function as receptors for Wnt and are generally coupled to G proteins. The frizzled-9 gene is located within the Williams Syndrome common deleted region at chromosomal band 7q11.23. Heterozygous deletion of the frizzled-9 gene may contribute to the Williams Syndrome phenotype. In mouse, frizzled-9 overexpression can induce the hyperphosphorylation and relocalization of Dvl-1 from the cytoplasm to the cell membrane and cytosolic β-catenin accumulation. In rat, frizzled-9 is important in Wnt/β-catenin signaling in 293T cells. Frizzled-9 is expressed predominantly in brain, testis, eye, skeletal muscle, and kidney. Alternative Name :
Frizzled9; Frizzled 9; Frizzled3; Frizzled 3; Frizzled-3;Fz-9; hFz9; FzE6; CD349; FZD9; FZD3 Swiss-Prot :
O00144 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide Frizzled-9 (L591). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS2775 Frizzled-9 (L591) pAb.
Frizzled-9 (L591) Peptide Applications :
Blocking Background :
The frizzled gene, originally identified in Drosophila melanogaster, is involved in the development of tissue polarity. The mammalian homolog of frizzled as well as several secreted mammalian frizzled-related proteins (FRPs) have been described. The frizzled proteins contain seven transmembrane domains, a cysteine-rich domain in the extracellular region and a carboxy terminal Ser/Thr-xxx-Val motif. They function as receptors for Wnt and are generally coupled to G proteins. The frizzled-9 gene is located within the Williams Syndrome common deleted region at chromosomal band 7q11.23. Heterozygous deletion of the frizzled-9 gene may contribute to the Williams Syndrome phenotype. In mouse, frizzled-9 overexpression can induce the hyperphosphorylation and relocalization of Dvl-1 from the cytoplasm to the cell membrane and cytosolic β-catenin accumulation. In rat, frizzled-9 is important in Wnt/β-catenin signaling in 293T cells. Frizzled-9 is expressed predominantly in brain, testis, eye, skeletal muscle, and kidney. Alternative Name :
Frizzled9; Frizzled 9; Frizzled3; Frizzled 3; Frizzled-3;Fz-9; hFz9; FzE6; CD349; FZD9; FZD3 Swiss-Prot :
O00144 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide Frizzled-9 (L591). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS2775 Frizzled-9 (L591) pAb.
Blocking peptide available as BS2775PP