CRF (R153) Peptide 
Datasheet
COA
MSDS
SHIP
Product Name :
CRF (R153) Peptide Applications :
Blocking Background :
Individuals suffering from Alzheimer’s disease (AD) exhibit dramatic reductions in the content of corticotropin-releasing factor (CRF), increased expression of CRF receptors (CRFRs) and abnormalities in neuronal morphology in affected brain areas. In addition, AD patients show decreased concentrations of CRF in their cerebrospinal fluid, which may contribute to their cognitive impairment. A high affinity CRF binding protein, designated CRF-BP, has been discovered in post-mortem brain samples from AD patients. CRF-BP serves to bind and inactivate CRF, reducing the pool of “free CRF” available to bind CRFRs. Two CRFRs, designated CRF-RI and CFR-RII, have been described and exhibit distinct brain localizations. Alternative Name :
Corticoliberin; Corticotropin-releasing factor; CRF; Corticotropin-releasing hormone; CRH Swiss-Prot :
P06850 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide CRF (R153). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS2869 CRF (R153) pAb.
CRF (R153) Peptide Applications :
Blocking Background :
Individuals suffering from Alzheimer’s disease (AD) exhibit dramatic reductions in the content of corticotropin-releasing factor (CRF), increased expression of CRF receptors (CRFRs) and abnormalities in neuronal morphology in affected brain areas. In addition, AD patients show decreased concentrations of CRF in their cerebrospinal fluid, which may contribute to their cognitive impairment. A high affinity CRF binding protein, designated CRF-BP, has been discovered in post-mortem brain samples from AD patients. CRF-BP serves to bind and inactivate CRF, reducing the pool of “free CRF” available to bind CRFRs. Two CRFRs, designated CRF-RI and CFR-RII, have been described and exhibit distinct brain localizations. Alternative Name :
Corticoliberin; Corticotropin-releasing factor; CRF; Corticotropin-releasing hormone; CRH Swiss-Prot :
P06850 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide CRF (R153). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS2869 CRF (R153) pAb.
Blocking peptide available as BS2869PP