GABAA Rβ2 (R431) Peptide 
Datasheet
COA
MSDS
SHIP
Product Name :
GABAA Rβ2 (R431) Peptide Applications :
Blocking Background :
GAD-65 and GAD-67, glutamate decarboxylases, function to catalyze the production of GABA (gamma-aminobutyric acid). In the central nervous system GABA functions as the main inhibitory transmitter by increasing a Cl- conductance that inhibits neuronal firing. GABA has been shown to activate both ionotropic (GABAA) and metabotropic (GABAB) receptors as well as a third class of receptors called GABAC. Both GABAA and GABAC are ligand-gated ion channels, however, they are structurally and functionally distinct. Members of the GABAA receptor family include GABAA Rα1-6, GABAA R β1-3, GABAA Rγ1-3, GABAA Rδ, GABAA Rε, GABAA Rρ1 and GABAA Rρ2. The GABAB family is composed of GABAB R1α and GABAB R1β. GABA transporters have also been identified and include GABA T-1, GABA T-2 and GABA T-3 (also designated GAT-1, -2, and -3). The GABA transporters function to terminate GABA action. Alternative Name :
Gamma-aminobutyric acid receptor subunit beta-2; GABA(A) receptor subunit beta-2; GABRB2; GABAARβ2 Swiss-Prot :
P47870 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide GABAA Rβ2 (R431). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS2907 GABAA Rβ2 (R431) pAb.
GABAA Rβ2 (R431) Peptide Applications :
Blocking Background :
GAD-65 and GAD-67, glutamate decarboxylases, function to catalyze the production of GABA (gamma-aminobutyric acid). In the central nervous system GABA functions as the main inhibitory transmitter by increasing a Cl- conductance that inhibits neuronal firing. GABA has been shown to activate both ionotropic (GABAA) and metabotropic (GABAB) receptors as well as a third class of receptors called GABAC. Both GABAA and GABAC are ligand-gated ion channels, however, they are structurally and functionally distinct. Members of the GABAA receptor family include GABAA Rα1-6, GABAA R β1-3, GABAA Rγ1-3, GABAA Rδ, GABAA Rε, GABAA Rρ1 and GABAA Rρ2. The GABAB family is composed of GABAB R1α and GABAB R1β. GABA transporters have also been identified and include GABA T-1, GABA T-2 and GABA T-3 (also designated GAT-1, -2, and -3). The GABA transporters function to terminate GABA action. Alternative Name :
Gamma-aminobutyric acid receptor subunit beta-2; GABA(A) receptor subunit beta-2; GABRB2; GABAARβ2 Swiss-Prot :
P47870 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide GABAA Rβ2 (R431). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS2907 GABAA Rβ2 (R431) pAb.
Blocking peptide available as BS2907PP