PUMA (R169) Peptide 
Datasheet
COA
MSDS
SHIP
Product Name :
PUMA (R169) Peptide Applications :
Blocking Background :
PUMA (Bcl-2 binding component 3, JFY1, PUMA/JFY1) is a mitochondrial pro-apoptotic Bcl-2 homology domain (BH3)-only protein that induces rapid apoptosis through a Bax- and mitochondria-dependent pathway. The PUMA gene encodes four proteins originating from different splice variants of the same transcript: PUMAα, β, γ and δ. Both PUMAα and PUMAβ contain a BH3 domain, while PUMAγ and PUMAδ lack this domain. The BH3 domain is essential for binding of PUMAα and PUMAβ to Bcl-2 or Bcl-xL. PUMA is an initiator of γ-radiation apoptosis and glucocorticoid-induced apoptosis in lymphoid cells in vivo. Bcl-2 family members generally regulate apoptosis and transmit death signals to mitochondria. Members of this family include both pro- and anti-apoptotic proteins that share homologous sequences known as Bcl-2 homology domains (BH1-4). The BH3 proteins, BID, NOXA, PUMA, NBK, Bim and Bad, are all pro-apoptotic and share sequence homology within the amphipathic α-helical BH3 region. Alternative Name :
BBC 3 antibody BBC3 antibody BCL 2 binding component 3 antibody BCL2 binding component 3 antibody JFY 1 antibody JFY1 antibody p53 up regulated modulator of apoptosis antibody p53 Upregulated Modulator of Apoptosis antibody PUMA alpha antibody PUMA/JFY1 antibody Swiss-Prot :
Q9BXH1 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide PUMA (R169). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS2922 PUMA (R169) pAb.
PUMA (R169) Peptide Applications :
Blocking Background :
PUMA (Bcl-2 binding component 3, JFY1, PUMA/JFY1) is a mitochondrial pro-apoptotic Bcl-2 homology domain (BH3)-only protein that induces rapid apoptosis through a Bax- and mitochondria-dependent pathway. The PUMA gene encodes four proteins originating from different splice variants of the same transcript: PUMAα, β, γ and δ. Both PUMAα and PUMAβ contain a BH3 domain, while PUMAγ and PUMAδ lack this domain. The BH3 domain is essential for binding of PUMAα and PUMAβ to Bcl-2 or Bcl-xL. PUMA is an initiator of γ-radiation apoptosis and glucocorticoid-induced apoptosis in lymphoid cells in vivo. Bcl-2 family members generally regulate apoptosis and transmit death signals to mitochondria. Members of this family include both pro- and anti-apoptotic proteins that share homologous sequences known as Bcl-2 homology domains (BH1-4). The BH3 proteins, BID, NOXA, PUMA, NBK, Bim and Bad, are all pro-apoptotic and share sequence homology within the amphipathic α-helical BH3 region. Alternative Name :
BBC 3 antibody BBC3 antibody BCL 2 binding component 3 antibody BCL2 binding component 3 antibody JFY 1 antibody JFY1 antibody p53 up regulated modulator of apoptosis antibody p53 Upregulated Modulator of Apoptosis antibody PUMA alpha antibody PUMA/JFY1 antibody Swiss-Prot :
Q9BXH1 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide PUMA (R169). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS2922 PUMA (R169) pAb.
Blocking peptide available as BS2922PP