POT1 (N296) Peptide 
Datasheet
COA
MSDS
SHIP
Product Name :
POT1 (N296) Peptide Applications :
Blocking Background :
POT1 is a component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini. It is a component of the double-stranded telomeric DNA-binding TRF1 complex which is involved in the regulation of telomere length by cis-inhibition of telomerase. Pot1 also acts as a single-stranded telomeric DNA-binding protein and thus may act as a downstream effector of the TRF1 complex and may transduce information about telomere maintenance and/or length to the telomere terminus. It binds to two or more telomeric single-stranded 5'-TTAGGG-3' repeats (G-strand) and with high specificity to a minimal telomeric single-stranded 5'-TAGGGTTAG-3' sequence. Its activity is TERT dependent but it does not increase TERT activity. Alternative Name :
Protection of telomeres protein 1; hPot1; POT1-like telomere end-binding protein; POT1 Swiss-Prot :
Q9NUX5 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide POT1 (N296). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS2933 POT1 (N296) pAb.
POT1 (N296) Peptide Applications :
Blocking Background :
POT1 is a component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini. It is a component of the double-stranded telomeric DNA-binding TRF1 complex which is involved in the regulation of telomere length by cis-inhibition of telomerase. Pot1 also acts as a single-stranded telomeric DNA-binding protein and thus may act as a downstream effector of the TRF1 complex and may transduce information about telomere maintenance and/or length to the telomere terminus. It binds to two or more telomeric single-stranded 5'-TTAGGG-3' repeats (G-strand) and with high specificity to a minimal telomeric single-stranded 5'-TAGGGTTAG-3' sequence. Its activity is TERT dependent but it does not increase TERT activity. Alternative Name :
Protection of telomeres protein 1; hPot1; POT1-like telomere end-binding protein; POT1 Swiss-Prot :
Q9NUX5 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide POT1 (N296). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS2933 POT1 (N296) pAb.
Blocking peptide available as BS2933PP