Myotubularin (Y290) Peptide 
Datasheet
COA
MSDS
SHIP
Product Name :
Myotubularin (Y290) Peptide Applications :
Blocking Background :
Human MTM1, a 603 amino-acid protein, is mutated in myotubular myopathy. The largely related protein hMTMR2 is found mutated in a recessive form of Charcot-Marie-tooth neuropathy. Myotubularin is primarily a lipid phosphatase that acts on hosphatidylinositol 3-monophosphate and is involved in the regulation of the phosphatidylinositol 3-kinase (PI 3-kinase) pathway and membrane trafficking. Wildtype myotubularin can directly dephosphorylate PI 3-P and PI 4-P in vitro. Thus, it decreases PI 3-P levels by down-regulating PI 3-K activity and by facilitating the degradation of PI 3-P. Alternative Name :
AF073996; CG2; CNM; CNM; KIAA4176; mKIAA4176; Mtm; Mtm1; MTM1; MTMX; MTMX; Myotubular myopathy 1; Myotubular myopathy 1; Myotubularin; XLMTM; XLMTM; Swiss-Prot :
Q13496 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide Myotubularin (Y290). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS2971 Myotubularin (Y290) pAb.
Myotubularin (Y290) Peptide Applications :
Blocking Background :
Human MTM1, a 603 amino-acid protein, is mutated in myotubular myopathy. The largely related protein hMTMR2 is found mutated in a recessive form of Charcot-Marie-tooth neuropathy. Myotubularin is primarily a lipid phosphatase that acts on hosphatidylinositol 3-monophosphate and is involved in the regulation of the phosphatidylinositol 3-kinase (PI 3-kinase) pathway and membrane trafficking. Wildtype myotubularin can directly dephosphorylate PI 3-P and PI 4-P in vitro. Thus, it decreases PI 3-P levels by down-regulating PI 3-K activity and by facilitating the degradation of PI 3-P. Alternative Name :
AF073996; CG2; CNM; CNM; KIAA4176; mKIAA4176; Mtm; Mtm1; MTM1; MTMX; MTMX; Myotubular myopathy 1; Myotubular myopathy 1; Myotubularin; XLMTM; XLMTM; Swiss-Prot :
Q13496 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide Myotubularin (Y290). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS2971 Myotubularin (Y290) pAb.
Blocking peptide available as BS2971PP