ZO-2 (Q1112) Peptide 
Datasheet
COA
MSDS
SHIP
Product Name :
ZO-2 (Q1112) Peptide Applications :
Blocking Background :
Tight junctions are complexes of proteins that create intercellular boundaries between the plasma membrane domains of epithelial and endothelial cells. Many of the tight junction-associated proteins are members of the membraneassociated guanylate kinase (MAGUK) family and include Occludin, ZO-1, ZO-2 and ZO-3. These proteins are thought to have both structural and signaling roles, and are characteristically defined by three protein-protein interaction modules: the PDZ domain, the SH3 domain and the guanylate kinase (GuK) domain. ZO-1 forms complexes with either ZO-2 or ZO-3. In addition, these proteins can also associate with Claudin, Occludin and F-Actin at tight junction stands, where they provide a linkage between the Actin cytoskeleton and the tight junction. ZO-1 expression is significantly reduced in many breast cancer lines. ZO-2 and ZO-3 are ubiquitously expressed within epithelial tight junctions, and unlike ZO-1, which is also expressed at cell junctions of cardiac myocytes, ZO-2 is not expressed in nonepithelial tissue. Alternative Name :
Tight junction protein ZO-2; Tight junction protein 2; Zona occludens protein 2; Zonula occludens protein 2; X104; ZO2; TJP2 Swiss-Prot :
Q9UDY2 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide ZO-2 (Q1112). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS3192 ZO-2 (Q1112) pAb.
ZO-2 (Q1112) Peptide Applications :
Blocking Background :
Tight junctions are complexes of proteins that create intercellular boundaries between the plasma membrane domains of epithelial and endothelial cells. Many of the tight junction-associated proteins are members of the membraneassociated guanylate kinase (MAGUK) family and include Occludin, ZO-1, ZO-2 and ZO-3. These proteins are thought to have both structural and signaling roles, and are characteristically defined by three protein-protein interaction modules: the PDZ domain, the SH3 domain and the guanylate kinase (GuK) domain. ZO-1 forms complexes with either ZO-2 or ZO-3. In addition, these proteins can also associate with Claudin, Occludin and F-Actin at tight junction stands, where they provide a linkage between the Actin cytoskeleton and the tight junction. ZO-1 expression is significantly reduced in many breast cancer lines. ZO-2 and ZO-3 are ubiquitously expressed within epithelial tight junctions, and unlike ZO-1, which is also expressed at cell junctions of cardiac myocytes, ZO-2 is not expressed in nonepithelial tissue. Alternative Name :
Tight junction protein ZO-2; Tight junction protein 2; Zona occludens protein 2; Zonula occludens protein 2; X104; ZO2; TJP2 Swiss-Prot :
Q9UDY2 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide ZO-2 (Q1112). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS3192 ZO-2 (Q1112) pAb.
Blocking peptide available as BS3192PP