TRH-R1 (W234) Peptide 
Datasheet
COA
MSDS
SHIP
Product Name :
TRH-R1 (W234) Peptide Applications :
Blocking Background :
Thyrotrophin-releasing hormone (TRH) is a hypothalamic tripeptide that stimulates, via its receptor in the anterior pituitary gland, the release of thyrotrophin (TSH) and prolactin. The TRH receptors, TRH-R1 and TRH-R2, are G protein-coupled proteins containing seven transmembrane domains and other conserved regions. In rat, two isoforms exist, TRH-R (412) and TRH-R (387), that differ at their carboxy termini. TRH receptors are distributed throughout the central and peripheral nervous systems and are present in a variety of tissues. TRH-R2 displays 50% homology to TRH-R1 and is more restricted to the central nervous system than TRH-R1. Mutation in the TRH receptor gene is associated with isolated central hypothyroidism, a rare disorder characterized by insufficient TSH secretion resulting in low levels of thyroid hormones. Alternative Name :
Thyrotropin-releasing hormone receptor; TRH-R; Thyroliberin receptor; TRHR Swiss-Prot :
P34981 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide TRH-R1 (W234). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS3241 TRH-R1 (W234) pAb.
TRH-R1 (W234) Peptide Applications :
Blocking Background :
Thyrotrophin-releasing hormone (TRH) is a hypothalamic tripeptide that stimulates, via its receptor in the anterior pituitary gland, the release of thyrotrophin (TSH) and prolactin. The TRH receptors, TRH-R1 and TRH-R2, are G protein-coupled proteins containing seven transmembrane domains and other conserved regions. In rat, two isoforms exist, TRH-R (412) and TRH-R (387), that differ at their carboxy termini. TRH receptors are distributed throughout the central and peripheral nervous systems and are present in a variety of tissues. TRH-R2 displays 50% homology to TRH-R1 and is more restricted to the central nervous system than TRH-R1. Mutation in the TRH receptor gene is associated with isolated central hypothyroidism, a rare disorder characterized by insufficient TSH secretion resulting in low levels of thyroid hormones. Alternative Name :
Thyrotropin-releasing hormone receptor; TRH-R; Thyroliberin receptor; TRHR Swiss-Prot :
P34981 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide TRH-R1 (W234). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS3241 TRH-R1 (W234) pAb.
Blocking peptide available as BS3241PP