GRK1 (A17) Peptide 
Datasheet
COA
MSDS
SHIP
Product Name :
GRK1 (A17) Peptide Applications :
Blocking Background :
Heterotrimeric G protein-mediated signal transduction is a dynamically regulated process with the intensity of signal decreasing over time despite the continued presence of the agonist. This phenomenon, referred to as agonistmediated desensitization, involves phosphorylation of the receptor by two classes of enzymes. The first class is comprised of the second messengerregulated kinases, such as c-AMP dependent protein kinase A and protein kinase C. The second class includes the G protein-coupled receptor kinases (GRKs). At least seven members of the GRK family have been identified. These include rhodopsin kinase (GRK 1α and β); two forms of β-adrenergic receptor kinase: GRK 2 (βARK, βARK1) and GRK 3 (βARK2); IT-11 (GRK 4); GRK 5; GRK 6; and GRK 7. Phosphorylation of receptors by GRKs appears to be strictly dependent on the receptor being in its agonist-activated state. Alternative Name :
Rhodopsin kinase; RK; EC=2.7.11.14; G protein-coupled receptor kinase 1; RHOK; GRK1 Swiss-Prot :
Q15835 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide GRK1 (A17). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS3251 GRK1 (A17) pAb.
GRK1 (A17) Peptide Applications :
Blocking Background :
Heterotrimeric G protein-mediated signal transduction is a dynamically regulated process with the intensity of signal decreasing over time despite the continued presence of the agonist. This phenomenon, referred to as agonistmediated desensitization, involves phosphorylation of the receptor by two classes of enzymes. The first class is comprised of the second messengerregulated kinases, such as c-AMP dependent protein kinase A and protein kinase C. The second class includes the G protein-coupled receptor kinases (GRKs). At least seven members of the GRK family have been identified. These include rhodopsin kinase (GRK 1α and β); two forms of β-adrenergic receptor kinase: GRK 2 (βARK, βARK1) and GRK 3 (βARK2); IT-11 (GRK 4); GRK 5; GRK 6; and GRK 7. Phosphorylation of receptors by GRKs appears to be strictly dependent on the receptor being in its agonist-activated state. Alternative Name :
Rhodopsin kinase; RK; EC=2.7.11.14; G protein-coupled receptor kinase 1; RHOK; GRK1 Swiss-Prot :
Q15835 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide GRK1 (A17). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS3251 GRK1 (A17) pAb.
Blocking peptide available as BS3251PP