GFRα-4 (P178) Peptide 
Datasheet
COA
MSDS
SHIP
Product Name :
GFRα-4 (P178) Peptide Applications :
Blocking Background :
Glial cell line-derived neurotrophic factor (GDNF) and the related neurotrophic factor neurturin (NTN) are potent survival factors for central and peripheral neurons. Receptors for these factors include GFRα-1 (previously designated GDNFR-α), GFRα-2 (also designated RETL2), GFRα-3 and GFRα-4 (also known as persephin receptor). The receptors do not contain transmembrane domains and are attached to the cell membrane by glycosylphosphoinositol linkage. Binding of GDNF or NTN to one of these receptors leads to the activation of the tyrosine kinase Ret. GFRα-4 mediates the activation and GDNF-induced autophosphorylation of the RET receptor. It is mainly expressed in the adult thyroid gland, but lower levels may also be detected in fetal adrenal and thyroid glands. Alternative Name :
GDNF family receptor alpha-4; GDNF receptor alpha-4; GDNFR-alpha-4; GFR-alpha-4; Persephin receptor; GFRA4 Swiss-Prot :
Q9GZZ7 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide GFRα-4 (P178). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS3304 GFRα-4 (P178) pAb.
GFRα-4 (P178) Peptide Applications :
Blocking Background :
Glial cell line-derived neurotrophic factor (GDNF) and the related neurotrophic factor neurturin (NTN) are potent survival factors for central and peripheral neurons. Receptors for these factors include GFRα-1 (previously designated GDNFR-α), GFRα-2 (also designated RETL2), GFRα-3 and GFRα-4 (also known as persephin receptor). The receptors do not contain transmembrane domains and are attached to the cell membrane by glycosylphosphoinositol linkage. Binding of GDNF or NTN to one of these receptors leads to the activation of the tyrosine kinase Ret. GFRα-4 mediates the activation and GDNF-induced autophosphorylation of the RET receptor. It is mainly expressed in the adult thyroid gland, but lower levels may also be detected in fetal adrenal and thyroid glands. Alternative Name :
GDNF family receptor alpha-4; GDNF receptor alpha-4; GDNFR-alpha-4; GFR-alpha-4; Persephin receptor; GFRA4 Swiss-Prot :
Q9GZZ7 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide GFRα-4 (P178). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS3304 GFRα-4 (P178) pAb.
Blocking peptide available as BS3304PP