FTβ (E285) Peptide 
Datasheet
COA
MSDS
SHIP
Product Name :
FTβ (E285) Peptide Applications :
Blocking Background :
Mammalian protein farnesyl transferases are heterodimeric proteins containing two nonidentical α and β subunits that attach farnesyl residues to a cysteine at the fourth position from the COOH terminus of several proteins, including nuclear lamins and p21Ras proteins. The natural substrates contain the Cys-A-A-Xaa recognition sequence, where the A residues are aliphatic and Xaa represents methionine, serine, glutamine or cysteine. The purified farnesyl transferase is an α-β heterodimer. The β subunit binds the peptide substrate while the α subunit is suspected to participate in formation of a stable complex with the substrate farnesyl pyrophosphate. The α subunit is shared with a second prenyl transferase, geranyl-geranyl transferase, that attaches 20 carbon geranylgeranyl to Ras related proteins that terminate in a Cys-A-A-Xaa recognition site in which Xaa is leucine. Alternative Name :
FNTB; FTase-beta; Protein farnesyltransferase subunit beta; Swiss-Prot :
P49356 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide FTβ (E285). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS3377 FTβ (E285) pAb.
FTβ (E285) Peptide Applications :
Blocking Background :
Mammalian protein farnesyl transferases are heterodimeric proteins containing two nonidentical α and β subunits that attach farnesyl residues to a cysteine at the fourth position from the COOH terminus of several proteins, including nuclear lamins and p21Ras proteins. The natural substrates contain the Cys-A-A-Xaa recognition sequence, where the A residues are aliphatic and Xaa represents methionine, serine, glutamine or cysteine. The purified farnesyl transferase is an α-β heterodimer. The β subunit binds the peptide substrate while the α subunit is suspected to participate in formation of a stable complex with the substrate farnesyl pyrophosphate. The α subunit is shared with a second prenyl transferase, geranyl-geranyl transferase, that attaches 20 carbon geranylgeranyl to Ras related proteins that terminate in a Cys-A-A-Xaa recognition site in which Xaa is leucine. Alternative Name :
FNTB; FTase-beta; Protein farnesyltransferase subunit beta; Swiss-Prot :
P49356 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide FTβ (E285). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS3377 FTβ (E285) pAb.
Blocking peptide available as BS3377PP