AGER / RAGE (E182) Peptide 
Datasheet
COA
MSDS
SHIP
Product Name :
AGER / RAGE (E182) Peptide Applications :
Blocking Background :
Advanced glycosylation end products of proteins (AGEs) are nonenzymatically glycosylated proteins that are associated with a variety of conditions, including diabetes and other vascular disorders, as well as amyloidosis. These proteins regulate cellular functions via specific cell surface acceptor molecules, such as RAGE (receptor for advanced glycosylation end products). RAGE is a type 1 membrane protein that is found on the surface of endothelial cells, mononuclear phagocytes and vascular smooth muscle cells. Binding of AGEs to RAGE results in the induction of cellular oxidant stress and activation of the transcription factor NFkB. Evidence suggests that the induction of oxidant stress results in the activation of an intracellular cascade involving p21 ras and MAP kinase, which leads to activation of transcription. Alternative Name :
Receptor for advanced glycosylation end products; Advanced glycosylation end product-specific receptor; AGER; RAGE Swiss-Prot :
Q15109 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide AGER / RAGE (E182). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS3448 AGER / RAGE (E182) pAb.
AGER / RAGE (E182) Peptide Applications :
Blocking Background :
Advanced glycosylation end products of proteins (AGEs) are nonenzymatically glycosylated proteins that are associated with a variety of conditions, including diabetes and other vascular disorders, as well as amyloidosis. These proteins regulate cellular functions via specific cell surface acceptor molecules, such as RAGE (receptor for advanced glycosylation end products). RAGE is a type 1 membrane protein that is found on the surface of endothelial cells, mononuclear phagocytes and vascular smooth muscle cells. Binding of AGEs to RAGE results in the induction of cellular oxidant stress and activation of the transcription factor NFkB. Evidence suggests that the induction of oxidant stress results in the activation of an intracellular cascade involving p21 ras and MAP kinase, which leads to activation of transcription. Alternative Name :
Receptor for advanced glycosylation end products; Advanced glycosylation end product-specific receptor; AGER; RAGE Swiss-Prot :
Q15109 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide AGER / RAGE (E182). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS3448 AGER / RAGE (E182) pAb.
Blocking peptide available as BS3448PP