Connexin 45 (N361) Peptide 
Datasheet
COA
MSDS
SHIP
Product Name :
Connexin 45 (N361) Peptide Applications :
Blocking Background :
Connexin proteins share a common topology of four transmembrane α-helical domains, two extracellular loops, a cytoplasmic loop and cytoplasmic N- and C-termini. Many of the key functional differences arise from specific amino acid substitutions in the most highly conserved domains, the transmembrane and extracellular regions. Each of the approximately 20 connexin isoforms produces channels with distinct permeabilities and electrical and chemical sensitivities; therefore, one connexin usually cannot fully substitute for another. Consequently, a wide variety of malignant phenotypes associate with decreased connexin expression and gap junction communication, dependent on the particular connexin that is effected. For instance, downregulation of connexin 45 in the left ventricle associates with end-stage heart failure due both to ischaemic cardiomyopathy and idiopathic dilated cardiomyopathy. Alternative Name :
Gap junction gamma-1 protein; Connexin-45; Connexin45; Cx45; Gap junction alpha-7 protein; GJC1; GJA7 Swiss-Prot :
P36383 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide Connexin 45 (N361). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS3470 Connexin 45 (N361) pAb.
Connexin 45 (N361) Peptide Applications :
Blocking Background :
Connexin proteins share a common topology of four transmembrane α-helical domains, two extracellular loops, a cytoplasmic loop and cytoplasmic N- and C-termini. Many of the key functional differences arise from specific amino acid substitutions in the most highly conserved domains, the transmembrane and extracellular regions. Each of the approximately 20 connexin isoforms produces channels with distinct permeabilities and electrical and chemical sensitivities; therefore, one connexin usually cannot fully substitute for another. Consequently, a wide variety of malignant phenotypes associate with decreased connexin expression and gap junction communication, dependent on the particular connexin that is effected. For instance, downregulation of connexin 45 in the left ventricle associates with end-stage heart failure due both to ischaemic cardiomyopathy and idiopathic dilated cardiomyopathy. Alternative Name :
Gap junction gamma-1 protein; Connexin-45; Connexin45; Cx45; Gap junction alpha-7 protein; GJC1; GJA7 Swiss-Prot :
P36383 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide Connexin 45 (N361). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS3470 Connexin 45 (N361) pAb.
Blocking peptide available as BS3470PP