BRCA1 (P982) Peptide 
Datasheet
COA
MSDS
SHIP
Product Name :
BRCA1 (P982) Peptide Applications :
Blocking Background :
BRCA1 (breast and ovarian cancer susceptibility protein 1) is a nuclear phosphoprotein that plays a role in maintaining genomic stability and acts as a tumor suppressor. It combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as BASC (for BRCA1 associated genome surveillance complex). BRCA1 associates with RNA polymerase II, and through the C terminal domain, also interacts with histone deacetylase complex. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in the BRCA1 gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Alternative Name :
Breast cancer type 1 susceptibility protein; RING finger protein 53; BRCA1; RNF53 Swiss-Prot :
P38398 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide BRCA1 (P982). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS3576 BRCA1 (P982) pAb.
BRCA1 (P982) Peptide Applications :
Blocking Background :
BRCA1 (breast and ovarian cancer susceptibility protein 1) is a nuclear phosphoprotein that plays a role in maintaining genomic stability and acts as a tumor suppressor. It combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as BASC (for BRCA1 associated genome surveillance complex). BRCA1 associates with RNA polymerase II, and through the C terminal domain, also interacts with histone deacetylase complex. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in the BRCA1 gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Alternative Name :
Breast cancer type 1 susceptibility protein; RING finger protein 53; BRCA1; RNF53 Swiss-Prot :
P38398 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide BRCA1 (P982). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS3576 BRCA1 (P982) pAb.
Blocking peptide available as BS3576PP