Dok-1 (P356) Peptide 
Datasheet
COA
MSDS
SHIP
Product Name :
Dok-1 (P356) Peptide Applications :
Blocking Background :
Dok-1 associates with the Ras GTPase-activating protein (Ras GAP) upon tyrosine phosphorylation. Evidence suggests that Dok-1 (also designated p62dok) is a substrate of the constitutive tyrosine kinase activity of p210 Bcr-Abl, a fusion protein caused by the t(9;22) translocation and associated with chronic myelogenous leukemia. Dok-1, as well as the tyrosine kinase substrates IRS-1 and Cas, are members of a class of “docking” proteins which contain multiple tyrosine residues and putative SH2 binding sites. Dok-1 is suspected to be the substrate phosphorylated in response to stimulation by a number of growth factors, including PDGF, VEGF, insulin and IGF. Alternative Name :
Docking protein 1 62kD; Docking protein 1; DOK 1; DOK1; DOK1; Downstream of tyrosine kinase 1; p62(dok); P62DOK; pp62 Swiss-Prot :
Q99704 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide Dok-1 (P356). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS3649 Dok-1 (P356) pAb.
Dok-1 (P356) Peptide Applications :
Blocking Background :
Dok-1 associates with the Ras GTPase-activating protein (Ras GAP) upon tyrosine phosphorylation. Evidence suggests that Dok-1 (also designated p62dok) is a substrate of the constitutive tyrosine kinase activity of p210 Bcr-Abl, a fusion protein caused by the t(9;22) translocation and associated with chronic myelogenous leukemia. Dok-1, as well as the tyrosine kinase substrates IRS-1 and Cas, are members of a class of “docking” proteins which contain multiple tyrosine residues and putative SH2 binding sites. Dok-1 is suspected to be the substrate phosphorylated in response to stimulation by a number of growth factors, including PDGF, VEGF, insulin and IGF. Alternative Name :
Docking protein 1 62kD; Docking protein 1; DOK 1; DOK1; DOK1; Downstream of tyrosine kinase 1; p62(dok); P62DOK; pp62 Swiss-Prot :
Q99704 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide Dok-1 (P356). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS3649 Dok-1 (P356) pAb.
Blocking peptide available as BS3649PP