GCS-α-1 (D423) Peptide 
Datasheet
COA
MSDS
SHIP
Product Name :
GCS-α-1 (D423) Peptide Applications :
Blocking Background :
Guanylate cyclases belong to the adenylyl cyclase class-4/guanylyl cyclase family. There are two forms of guanylate cyclase, a soluble form (GCS or sGC), which act as receptors for nitric oxide and a membrane-bound receptor form (GC), which are peptide hormone receptors. The GC-C protein is composed of an extracellular domain, a single transmembrane domain, and a cytoplasmic region consisting of a kinase-like domain and a catalytic domain. It is expressed as two differentially glycosylated forms, a 130 kDa precursor form present in the endoplasmic reticulum and a 145 kDa form present on the plasma membrane. Ligand binding to the extracellular domain of GC-C promotes the accumulation of cGMP. GC-C acts as the receptor for heatstable enterotoxins, small peptides secreted by some pathogenic strains of E. coli that cause severe secretory diarrhea. GC-C also binds to guanylin and uroguanylin peptides, which modulate renal function in response to oral salt load. Alternative Name :
Guanylate cyclase soluble subunit alpha-3; GCS-alpha-3; EC=4.6.1.2; GCS-alpha-1; Soluble guanylate cyclase large subunit; GUC1A3; GUCSA3; GUCY1A1; GUCY1A3 Swiss-Prot :
Q02108 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide GCS-α-1 (D423). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS3670 GCS-α-1 (D423) pAb.
GCS-α-1 (D423) Peptide Applications :
Blocking Background :
Guanylate cyclases belong to the adenylyl cyclase class-4/guanylyl cyclase family. There are two forms of guanylate cyclase, a soluble form (GCS or sGC), which act as receptors for nitric oxide and a membrane-bound receptor form (GC), which are peptide hormone receptors. The GC-C protein is composed of an extracellular domain, a single transmembrane domain, and a cytoplasmic region consisting of a kinase-like domain and a catalytic domain. It is expressed as two differentially glycosylated forms, a 130 kDa precursor form present in the endoplasmic reticulum and a 145 kDa form present on the plasma membrane. Ligand binding to the extracellular domain of GC-C promotes the accumulation of cGMP. GC-C acts as the receptor for heatstable enterotoxins, small peptides secreted by some pathogenic strains of E. coli that cause severe secretory diarrhea. GC-C also binds to guanylin and uroguanylin peptides, which modulate renal function in response to oral salt load. Alternative Name :
Guanylate cyclase soluble subunit alpha-3; GCS-alpha-3; EC=4.6.1.2; GCS-alpha-1; Soluble guanylate cyclase large subunit; GUC1A3; GUCSA3; GUCY1A1; GUCY1A3 Swiss-Prot :
Q02108 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide GCS-α-1 (D423). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS3670 GCS-α-1 (D423) pAb.
Blocking peptide available as BS3670PP