TYK2 (V1048) Peptide 
Datasheet
COA
MSDS
SHIP
Product Name :
TYK2 (V1048) Peptide Applications :
Blocking Background :
Tyk 2 belongs to the family of non-receptor janus tyrosine kinases, which regulate a spectrum of cellular functions occurring downstream of activated cytokine receptors in the lympho-hematopoietic system. Immunological stimuli, such as interferons and cytokines, recruit STAT transcription factors to the cytokine receptor where Tyk 2 is associated. Tyk 2 then phosphorylates proximal STAT factors, which subsequently dimerize, translocate to the nucleus, and bind to cis elements upstream of target gene promoters to regulating transcription. The canonical JAK-STAT pathway is integral to maintaining a normal immune system by stimulating proliferation, differentiation, survival, and host resistance to pathogens. Cytokine induced pro-inflammatory responses are attractive targets for anti-inflammatory therapies, specifically at the level of Jak-STAT signaling. Alternative Name :
JTK 1; Protein Tyrosine Kinase 2; JTK 1; Protein Tyrosine Kinase 2; TYK 2; Tyrosine kinase 2; JTK1; Non receptor tyrosine protein kinase TYK2; Non receptor tyrosine protein kinase 2 Swiss-Prot :
P29597 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide TYK2 (V1048). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS3713 TYK2 (V1048) pAb.
TYK2 (V1048) Peptide Applications :
Blocking Background :
Tyk 2 belongs to the family of non-receptor janus tyrosine kinases, which regulate a spectrum of cellular functions occurring downstream of activated cytokine receptors in the lympho-hematopoietic system. Immunological stimuli, such as interferons and cytokines, recruit STAT transcription factors to the cytokine receptor where Tyk 2 is associated. Tyk 2 then phosphorylates proximal STAT factors, which subsequently dimerize, translocate to the nucleus, and bind to cis elements upstream of target gene promoters to regulating transcription. The canonical JAK-STAT pathway is integral to maintaining a normal immune system by stimulating proliferation, differentiation, survival, and host resistance to pathogens. Cytokine induced pro-inflammatory responses are attractive targets for anti-inflammatory therapies, specifically at the level of Jak-STAT signaling. Alternative Name :
JTK 1; Protein Tyrosine Kinase 2; JTK 1; Protein Tyrosine Kinase 2; TYK 2; Tyrosine kinase 2; JTK1; Non receptor tyrosine protein kinase TYK2; Non receptor tyrosine protein kinase 2 Swiss-Prot :
P29597 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide TYK2 (V1048). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS3713 TYK2 (V1048) pAb.
Blocking peptide available as BS3713PP