LRP1 (G4514) Peptide 
Datasheet
COA
MSDS
SHIP
Product Name :
LRP1 (G4514) Peptide Applications :
Blocking Background :
Members of the LDL receptor gene family, including LDLR (low density lipoprotein receptor), LRP1 (low density lipoprotein related protein), Megalin (also designated GP330), VLDLR (very low density lipoprotein receptor) and ApoER2 are characterized by a cluster of cysteine-rich class A repeats, epidermal growth factor (EGF)-like repeats, YWTD repeats and an O-linked sugar domain. LRP1, also designated LRP and α-2-Macroglobulin receptor, is an endocytic receptor that mediates the uptake of at least 15 ligands, including α-2-Macroglobulin and apoE. LRP1 is cleaved into a membrane subunit and an extracellular subunit, which remain non-covalently associated. Proper folding and trafficking of LRP1 is facilitated by the receptor-associated protein (RAP), a molecular chaperone. The uptake of all known ligands through LRP1 can be blocked by RAP, which induces a conformational change in the receptor that renders it unable to bind ligands. LRP1, which is expressed in brain, liver and lung, is also implicated in Alzheimer’s disease (AD), as the human LRP gene localizes to a potential AD locus on chromosome 12. Alternative Name :
A2MR, Alpha 2 macroglobulin receptor, alpha 2MR, Alpha-2-macroglobulin receptor, APOER, Apolipoprotein E receptor, APR, CD 91, CD91, CD91 antigen, Low density lipoprotein receptor related protein 1, Low density lipoprotein related protein 1, Low-density lipoprotein receptor-related protein 1 intracellular domain, LRP 1, LRP 515, LRP 85, LRP, LRP ICD, LRP-1, LRP-515, LRP-85, Lrp1, LRP1 protein, LRP1, LRP515, LRP85, LRPICD, MGC88725, TGFBR 5, TGFBR5, Type V tgf beta receptor, Swiss-Prot :
Q07954 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide LRP1 (G4514). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS3761 LRP1 (G4514) pAb.
LRP1 (G4514) Peptide Applications :
Blocking Background :
Members of the LDL receptor gene family, including LDLR (low density lipoprotein receptor), LRP1 (low density lipoprotein related protein), Megalin (also designated GP330), VLDLR (very low density lipoprotein receptor) and ApoER2 are characterized by a cluster of cysteine-rich class A repeats, epidermal growth factor (EGF)-like repeats, YWTD repeats and an O-linked sugar domain. LRP1, also designated LRP and α-2-Macroglobulin receptor, is an endocytic receptor that mediates the uptake of at least 15 ligands, including α-2-Macroglobulin and apoE. LRP1 is cleaved into a membrane subunit and an extracellular subunit, which remain non-covalently associated. Proper folding and trafficking of LRP1 is facilitated by the receptor-associated protein (RAP), a molecular chaperone. The uptake of all known ligands through LRP1 can be blocked by RAP, which induces a conformational change in the receptor that renders it unable to bind ligands. LRP1, which is expressed in brain, liver and lung, is also implicated in Alzheimer’s disease (AD), as the human LRP gene localizes to a potential AD locus on chromosome 12. Alternative Name :
A2MR, Alpha 2 macroglobulin receptor, alpha 2MR, Alpha-2-macroglobulin receptor, APOER, Apolipoprotein E receptor, APR, CD 91, CD91, CD91 antigen, Low density lipoprotein receptor related protein 1, Low density lipoprotein related protein 1, Low-density lipoprotein receptor-related protein 1 intracellular domain, LRP 1, LRP 515, LRP 85, LRP, LRP ICD, LRP-1, LRP-515, LRP-85, Lrp1, LRP1 protein, LRP1, LRP515, LRP85, LRPICD, MGC88725, TGFBR 5, TGFBR5, Type V tgf beta receptor, Swiss-Prot :
Q07954 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide LRP1 (G4514). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS3761 LRP1 (G4514) pAb.
Blocking peptide available as BS3761PP