TAL1 (G116) Peptide 
Datasheet
COA
MSDS
SHIP
Product Name :
TAL1 (G116) Peptide Applications :
Blocking Background :
Activation of TAL1 characterizes up to 60% of cases of human T cell acute lymphoblastic leukemia, making it the most frequent gain-of-function mutation observed in this disorder. TAL1 (also designated SCL) is a serine phosphoprotein and basic helix-loop-helix transcription factor known to regulate embryonic hematopoiesis. This transcription factor binds as a heterodimer with E2A and HEB/HTF4 to a nucleotide sequence motif termed the E-box. In addition, leukemogenesis is accelerated dramatically by transgenic co-expression of TAL1 and the catalytic subunit of casein kinase IIalpha, a serine/ threonine protein kinase known to modulate the activity of other bHLH transcription factors. Alternative Name :
bHLHa17; TAL1; BHLHA17; SCL; TCL5; TAL-1; Swiss-Prot :
P17542 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide TAL1 (G116). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS3772 TAL1 (G116) pAb.
TAL1 (G116) Peptide Applications :
Blocking Background :
Activation of TAL1 characterizes up to 60% of cases of human T cell acute lymphoblastic leukemia, making it the most frequent gain-of-function mutation observed in this disorder. TAL1 (also designated SCL) is a serine phosphoprotein and basic helix-loop-helix transcription factor known to regulate embryonic hematopoiesis. This transcription factor binds as a heterodimer with E2A and HEB/HTF4 to a nucleotide sequence motif termed the E-box. In addition, leukemogenesis is accelerated dramatically by transgenic co-expression of TAL1 and the catalytic subunit of casein kinase IIalpha, a serine/ threonine protein kinase known to modulate the activity of other bHLH transcription factors. Alternative Name :
bHLHa17; TAL1; BHLHA17; SCL; TCL5; TAL-1; Swiss-Prot :
P17542 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide TAL1 (G116). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS3772 TAL1 (G116) pAb.
Blocking peptide available as BS3772PP