X11γ (R401) Peptide 
Datasheet
COA
MSDS
SHIP
Product Name :
X11γ (R401) Peptide Applications :
Blocking Background :
Amyloid β precursor protein (β APP) is a major constituent of the amyloid deposits in patients with Alzheimer’s disease. The amyloid β precursor is known to interact with several proteins, including the G heterotrimetric protein, APP-BP1, and X11. The neuronal, transmembrane protein X11 is known to bind to the amyloid β precurser protein via a phosphotyrosine binding (PTB) domain, reducing the secretion of cellular β APP and slowing β APP processing pathways. X11 binds specifically to the YENPTY motif, which is involved in the internalization of β APP. Multiple splice varitents of X11 have been identified, including X11 α, β and γ (also known as Mint 1, 2 and 3, respectively). Alternative Name :
X11 like 2 protein 2; X11gamma; X11L2; APBA3; lin 10; MGC:15815; Mint 3; Swiss-Prot :
O96018 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide X11γ (R401). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS3806 X11γ (R401) pAb.
X11γ (R401) Peptide Applications :
Blocking Background :
Amyloid β precursor protein (β APP) is a major constituent of the amyloid deposits in patients with Alzheimer’s disease. The amyloid β precursor is known to interact with several proteins, including the G heterotrimetric protein, APP-BP1, and X11. The neuronal, transmembrane protein X11 is known to bind to the amyloid β precurser protein via a phosphotyrosine binding (PTB) domain, reducing the secretion of cellular β APP and slowing β APP processing pathways. X11 binds specifically to the YENPTY motif, which is involved in the internalization of β APP. Multiple splice varitents of X11 have been identified, including X11 α, β and γ (also known as Mint 1, 2 and 3, respectively). Alternative Name :
X11 like 2 protein 2; X11gamma; X11L2; APBA3; lin 10; MGC:15815; Mint 3; Swiss-Prot :
O96018 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide X11γ (R401). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS3806 X11γ (R401) pAb.
Blocking peptide available as BS3806PP