GDF-15 (L64) Peptide 
Datasheet
COA
MSDS
SHIP
Product Name :
GDF-15 (L64) Peptide Applications :
Blocking Background :
Growth differentiation factor 15 (GDF-15), also known as PDF, MIC-1, PLAB, NAG-1 or PTGF-β, is a member of the transforming growth factor beta (TGF-beta) superfamily. Synthesized intracellularly, the protein is secreted as a dimer linked by disulfide bonds. Epithelial cells and macrophages are the sites of strongest GDF-15 expression, although it is widely expressed in adult tissue. In the brain, GDF-15 expression occurs in the choroid plexus, from which the protein is secreted into the cerebrospinal fluid. The gene for GDF-15 is responsive to p53 tumor suppressor protein, and in cultured cerebellar granule neurons GDF-15 can prevent cell death by the activation of Akt and inhibition of ERK. GDF-15 acts as a trophic factor for certain classes of neurons, promoting cell survival and differentiation. Overexpression of GDF-15 occurs in prostate cancer, and may be a means of diagnosis. Alternative Name :
anti-GDF15 antibody; GDF-15 antibody; MIC-1 antibody; MIC1 antibody; NAG-1 antibody; NRG-1 antibody; PDF antibody; PLAB antibody; PTGFB antibody Swiss-Prot :
Q99988 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide GDF-15 (L64). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS3872 GDF-15 (L64) pAb.
GDF-15 (L64) Peptide Applications :
Blocking Background :
Growth differentiation factor 15 (GDF-15), also known as PDF, MIC-1, PLAB, NAG-1 or PTGF-β, is a member of the transforming growth factor beta (TGF-beta) superfamily. Synthesized intracellularly, the protein is secreted as a dimer linked by disulfide bonds. Epithelial cells and macrophages are the sites of strongest GDF-15 expression, although it is widely expressed in adult tissue. In the brain, GDF-15 expression occurs in the choroid plexus, from which the protein is secreted into the cerebrospinal fluid. The gene for GDF-15 is responsive to p53 tumor suppressor protein, and in cultured cerebellar granule neurons GDF-15 can prevent cell death by the activation of Akt and inhibition of ERK. GDF-15 acts as a trophic factor for certain classes of neurons, promoting cell survival and differentiation. Overexpression of GDF-15 occurs in prostate cancer, and may be a means of diagnosis. Alternative Name :
anti-GDF15 antibody; GDF-15 antibody; MIC-1 antibody; MIC1 antibody; NAG-1 antibody; NRG-1 antibody; PDF antibody; PLAB antibody; PTGFB antibody Swiss-Prot :
Q99988 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide GDF-15 (L64). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS3872 GDF-15 (L64) pAb.
Blocking peptide available as BS3872PP