ARHGEF7 (Q344) Peptide 
Datasheet
COA
MSDS
SHIP
Product Name :
ARHGEF7 (Q344) Peptide Applications :
Blocking Background :
The serine/threonine kinase, p21 activated kinase (PAK), is a downstream effector of the small GTPases Cdc42 and Rac. PAK associates with Nck, the p85 and p110 subunits of PI3-kinase and PIX (PAK-interacting exchange factor) in a focal complex. The binding of PIX is necessary for the localization and activation of PAK in the Cdc42 to Rac signaling pathway, and this binding occurs through the high affinity of the N-terminal SH3 domain of PIX for a conserved proline rich PAK sequence. PIX exists as two isoforms, α and β, and both are highly expressed in heart, muscle and thymus tissues of human and rat. αPIX is phosphorylated via PDGF and EphB2 receptor signaling pathways or through association with PI3-kinase. The αPIX isoform predominantly acts as a guanine nucleotide exchange factor (GEF) on Rac, which may mediate lamellipodia formation. Alternative Name :
PIXβ; Rho guanine nucleotide exchange factor 7; Beta-Pix; COOL-1; PAK-interacting exchange factor beta; p85; ARHGEF7; COOL1; KIAA0142; P85SPR; PAK3BP; PIXB; Nbla10314 Swiss-Prot :
Q14155 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide ARHGEF7 (Q344). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS3929 ARHGEF7 (Q344) pAb.
ARHGEF7 (Q344) Peptide Applications :
Blocking Background :
The serine/threonine kinase, p21 activated kinase (PAK), is a downstream effector of the small GTPases Cdc42 and Rac. PAK associates with Nck, the p85 and p110 subunits of PI3-kinase and PIX (PAK-interacting exchange factor) in a focal complex. The binding of PIX is necessary for the localization and activation of PAK in the Cdc42 to Rac signaling pathway, and this binding occurs through the high affinity of the N-terminal SH3 domain of PIX for a conserved proline rich PAK sequence. PIX exists as two isoforms, α and β, and both are highly expressed in heart, muscle and thymus tissues of human and rat. αPIX is phosphorylated via PDGF and EphB2 receptor signaling pathways or through association with PI3-kinase. The αPIX isoform predominantly acts as a guanine nucleotide exchange factor (GEF) on Rac, which may mediate lamellipodia formation. Alternative Name :
PIXβ; Rho guanine nucleotide exchange factor 7; Beta-Pix; COOL-1; PAK-interacting exchange factor beta; p85; ARHGEF7; COOL1; KIAA0142; P85SPR; PAK3BP; PIXB; Nbla10314 Swiss-Prot :
Q14155 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide ARHGEF7 (Q344). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS3929 ARHGEF7 (Q344) pAb.
Blocking peptide available as BS3929PP