p-Bcr (Y177) Peptide 
Datasheet
COA
MSDS
SHIP
Product Name :
p-Bcr (Y177) Peptide Applications :
Blocking Background :
The Bcr gene, mapping on chromosome 22, was initially identified on the basis of its fusion with the c-Abl proto-oncogene on chromosome 9 resulting in the generation of the Philadelphia chromosome in 90-95% of patients with chronic myelogenous leukemia (CML). The Bcr gene encodes for the Breakpoint cluster region protein (Bcr). A consequence of this translocation is the generation of a Bcr/c-Abl mRNA encoding an activated c-Abl protein kinase. The Bcr gene has been shown to encode a 160 kDa GTPase-activating protein (GAP) specific for the Ras-related GTP-binding protein, Rac 1 p21. While it has been speculated that the Bcr protein may also stimulate Rac 2 p21 GTPase activity, it has no effect on Ras p21 or Rho p21 GTPases. Alternative Name :
Breakpoint cluster region protein; Renal carcinoma antigen NY-REN-26; BCR; BCR1; D22S11 Swiss-Prot :
P11274 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide p-Bcr (Y177). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS4026 p-Bcr (Y177) pAb.
p-Bcr (Y177) Peptide Applications :
Blocking Background :
The Bcr gene, mapping on chromosome 22, was initially identified on the basis of its fusion with the c-Abl proto-oncogene on chromosome 9 resulting in the generation of the Philadelphia chromosome in 90-95% of patients with chronic myelogenous leukemia (CML). The Bcr gene encodes for the Breakpoint cluster region protein (Bcr). A consequence of this translocation is the generation of a Bcr/c-Abl mRNA encoding an activated c-Abl protein kinase. The Bcr gene has been shown to encode a 160 kDa GTPase-activating protein (GAP) specific for the Ras-related GTP-binding protein, Rac 1 p21. While it has been speculated that the Bcr protein may also stimulate Rac 2 p21 GTPase activity, it has no effect on Ras p21 or Rho p21 GTPases. Alternative Name :
Breakpoint cluster region protein; Renal carcinoma antigen NY-REN-26; BCR; BCR1; D22S11 Swiss-Prot :
P11274 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide p-Bcr (Y177). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS4026 p-Bcr (Y177) pAb.
Blocking peptide available as BS4026PP